Evidence map›Paper›PMID 31109387›Full record

ArticleDevelopment and psychopathology2019

Excitability and irritability in preschoolers predicts later psychopathology: The importance of positive and negative emotion dysregulation.

Alecia C Vogel, Joshua J Jackson, Deanna M Barch, Rebecca Tillman, Joan L Luby

Open access · greenAbstract read
In one paragraph

Article in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  19. Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder.Journal of child psychology and psychiatry, and allied disciplines · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alecia C VogelDepartment of Psychiatry,Washington University in St. Louis School of Medicine,St. Louis,MO,USA.
Joshua J JacksonDepartment of Psychological and Brain Sciences,Washington University in St. Louis,St. Louis, MO,USA.
Deanna M BarchDepartment of Psychiatry,Washington University in St. Louis School of Medicine,St. Louis,MO,USA.
Rebecca TillmanDepartment of Psychiatry,Washington University in St. Louis School of Medicine,St. Louis,MO,USA.
Joan L LubyDepartment of Psychiatry,Washington University in St. Louis School of Medicine,St. Louis,MO,USA.
Washington University in St. Louis · US

Funding

NEUROIMAGING IN EARLY ONSET DEPRESSION: LONGITUDINAL ASSESSMENT OF BRAIN CHANGESR01MH090786 · NIMH · WASHINGTON UNIVERSITY · PI GILBERT, KIRSTEN, WHALEN, DIANA J · 2010 to 2025
$10.4M
Validation of Preschool Depressive SyndromeR01MH064769 · NIMH · WASHINGTON UNIVERSITY · PI LUBY, JOAN L. · 2003 to 2012
$7.7M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NIMH NIH HHS R01 MH064769NIMH NIH HHS R01 MH090786NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

Emotion dysregulation is a risk factor for the development of a variety of psychopathologic outcomes. In children, irritability, or dysregulated negative affect, has been the primary focus, as it predicts later negative outcomes even in very young children. However, dysregulation of positive emotion is increasingly recognized as a contributor to psychopathology. Here we used an exploratory factor analysis and defined four factors of emotion dysregulation: irritability, excitability, sadness, and anhedonia, in the preschool-age psychiatric assessment collected in a sample of 302 children ages 3-5 years enriched for early onset depression. The irritability and excitability factor scores defined in preschoolers predicted later diagnosis of mood and externalizing disorders when controlling for other factor scores, social adversity, maternal history of mood disorders, and externalizing diagnoses at baseline. The preschool excitability factor score predicted emotion lability in late childhood and early adolescence when controlling for other factor scores, social adversity, and maternal history. Both excitability and irritability factor scores in preschoolers predicted global functioning into the teen years and early adolescence, respectively. These findings underscore the importance of positive, as well as negative, affect dysregulation as early as the preschool years in predicting later psychopathology, which deserves both further study and clinical consideration.

Indexed as

AdolescentAffectAffective SymptomsArousalChild, PreschoolEmotionsFemaleHumansIrritable MoodMaleMood DisordersYoung Adultdepressionemotion dysregulationexploratory factor analysismood labilitypreschool

Identifiers

PMID31109387
PMCPMC7059859
OpenAlexW2945711459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.