Evidence map›Paper›PMID 31109309›Full record

SynthesisBMC cancer2019

A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews.

U Olsson Möller, I Beck, L Rydén, M Malmström

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04457895 (A Randomized, Open-labelled, Controlled Trial Evaluating the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.), which is not on this map. Cited by 81 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 9 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04457895 narecruitingnot on this mapstarted 2021, after this paper: background citation

A Randomized, Open-labelled, Controlled Trial Evaluating the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2021 to 2028Enrolled108ConditionsBreast CancerArmseducational yoga program, no intervention
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 9 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Pooled it
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  3. Effect of exercise on fatigue and depression in breastcancer women undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  13. The effects of early rehabilitation on physical and psychosocial functions after breast cancer surgery.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  15. Preventive effects of progressive resistance training of different intensities on breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  20. Breast cancer-related lymphedema and its treatment: how big is the financial impact?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Trial

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

U Olsson MöllerDepartment of Nursing and Integrated Health Sciences, Faculty of Medicine, Kristianstad University, Kristianstad, Sweden.
I BeckDepartment of Nursing and Integrated Health Sciences, Faculty of Medicine, Kristianstad University, Kristianstad, Sweden.
L RydénDepartment of Clinical Sciences Lund, Surgery, Lund University, Skåne University Hospital, Medicon Village 406, 223 81, Lund, Sweden. lisa.ryden@med.lu.se.
M MalmströmThe Institute for Palliative Care, Lund University and Region Skåne, Lund, Sweden.
Kristianstad University · SELund University · SESkåne University Hospital · SE

Funding

Governmental funding of clinical research within the NHS -Percy Falks Stiftelse för Forskning Beträffande Prostata- och Bröstcancer -The Swedish Breast Cancer Association -
6 · The paper itself

Abstract

backgroundBreast cancer (BC) is the most common type of cancer in women worldwide. Post-treatment, patients suffer from side effects and have various rehabilitation needs, which means that individualization is fundamental for optimal rehabilitation. This systematic review (SR) of SRs aims to evaluate the current evidence on rehabilitation interventions in female patients following BC treatment.

methodsFull-text SRs published in English from 2009 were searched in Embase, PubMed, Cinahl Complete, PsycINFO, AMED, SCOPUS, and Cochrane Library. INCLUSION CRITERIA: SRs of randomized or non-randomized controlled trials investigating the effects of rehabilitation interventions in women following BC treatment. All outcomes were considered. Methodological quality was evaluated using the AMSTAR 2 tool and interrater agreement was evaluated. Out of 1269 citations retrieved, 37 SRs were included.

resultsFive rehabilitation areas were identified: exercise and physical activity (PA), complementary and alternative medicine (CAM), yoga, lymphoedema treatment, and psychosocial interventions. The most solid evidence was found in exercise/PA and yoga. Exercise interventions improved outcomes such as shoulder mobility, lymphoedema, pain, fatigue and quality of life (QoL). Effects of yoga were shown on QoL, anxiety, depression, sleep disturbance, fatigue and gastrointestinal symptoms. The effect of CAM was shown on nausea, pain, fatigue, anger and anxiety but these results need to be interpreted with caution because of low methodological quality in included studies in the SRs. Among the lymphoedema treatments, positive effects were seen for resistance training on volume reduction and muscle strength and psychosocial interventions such as cognitive behavioural therapy had positive effects on QoL, anxiety, depression and mood disturbance.

conclusionsThis SR of SRs show solid positive effects of exercise/PA and yoga for women following BC treatment, and provides extended knowledge of the effects of CAM, yoga, lymphoedema treatment and psychosocial interventions. It is evident that more than one intervention could have positive effects on a specific symptom and that the effects depend not only on intervention type but also on how and when the intervention is provided. The results can be used as a foundation for individualized rehabilitation and aid health care professionals in meeting patients' individual needs and preferences.

trial registrationPROSPERO ( CRD42017060912 ).

Indexed as

Breast NeoplasmsExerciseFemaleHumansLymphedemaQuality of LifeResistance TrainingSystematic Reviews as TopicTreatment OutcomeYogaBreast cancer treatmentBreast neoplasmComplementary therapiesExerciseLymphoedemaPsychosocialQuality of lifeRehabilitationSystematic reviewYoga

Identifiers

PMID31109309
PMCPMC6528312
OpenAlexW2947113254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.