Evidence map›Paper›PMID 31109124›Full record

ArticleMolecules (Basel, Switzerland)2019

Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects.

Robert K Hofstetter, Felix Potlitz, Lukas Schulig, Simon Kim, Mahmoud Hasan, Andreas Link

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 19 citations in OpenAlex.

  1. Stereoselective Processes Based on σ-Hole Interactions.Molecules (Basel, Switzerland) · 2022
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert K HofstetterPharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany. hofstetter@uni-greifswald.de.ORCID 0000-0002-1077-9703
Felix PotlitzPharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany. felix.potlitz@gmail.com.
Lukas SchuligPharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany. lukas.schulig@uni-greifswald.de.ORCID 0000-0002-4614-3395
Simon KimDepartment of Trauma, Reconstructive Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany. kims@uni-greifswald.de.ORCID 0000-0002-7455-7421
Mahmoud HasanDepartment of Clinical Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, 17475 Greifswald, Germany. hasanm@uni-greifswald.de.
Andreas LinkPharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany. link@uni-greifswald.de.ORCID 0000-0003-1262-6636
Universität Greifswald · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral metabolites of ketamine exerting rapid-onset yet sustained antidepressant effects may be marketed directly in the future, but require chemo- and enantio-selective chromatographic methods for quality assurance and control. The chromatographic behavior of

Indexed as

AmyloseAntidepressive AgentsCarbon DioxideCelluloseChromatography, High Pressure LiquidChromatography, Supercritical FluidKetamineMolecular Docking SimulationPolysaccharidesReproducibility of ResultsStereoisomerismSurface PropertiesTemperatureAmyloseAntidepressive AgentsCarbon DioxideCelluloseKetaminePolysaccharideschiral resolutionchiral stationary phasecoateddepressionimmobilizedketaminemetabolitessub-ambient temperaturesubcritical fluid chromatographysupercritical CO2

Identifiers

PMID31109124
PMCPMC6572699
OpenAlexW2945336562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.