Evidence map›Paper›PMID 31109114›Full record

ArticleMolecules (Basel, Switzerland)2019

Effect of Geometrical Structure, Drying, and Synthetic Method on Aminated Chitosan-Coated Magnetic Nanoparticles Utility for HSA Effective Immobilization.

Marta Ziegler-Borowska, Kinga Mylkie, Mariana Kozlowska, Pawel Nowak, Dorota Chelminiak-Dudkiewicz, Anna Kozakiewicz, Anna Ilnicka, Anna Kaczmarek-Kedziera

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Effect of Aminated Chitosan-Coated FeInternational journal of molecular sciences · 2021
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. HSA-MnOTechnology in cancer research & treatment
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Marta Ziegler-BorowskaFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. martaz@chem.umk.pl.
Kinga MylkieFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. kinga.mylkie@o2.pl.
Mariana KozlowskaKarlsruhe Inst Technol, Inst Nanotechnol INT, Hermann von Helmholtz Pl 1, D-76344 Eggenstein-Leopoldshafen, Germany. mari.kozlowska@gmail.com.
Pawel NowakFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. nowak19981411@wp.pl.
Dorota Chelminiak-DudkiewiczFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. dorotachelminiak@wp.pl.
Anna KozakiewiczFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. akoza@umk.pl.
Anna IlnickaFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. ailnicka@umk.pl.
Anna Kaczmarek-KedzieraFaculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland. teoadk@umk.pl.
Nicolaus Copernicus University · PLKarlsruhe Institute of Technology · DE

Funding

Narodowe Centrum Nauki 2014/13/B/ST8/04342Narodowe Centrum Nauki 2014/15/D/NZ7/01805
6 · The paper itself

Abstract

Human serum albumin (HSA) is one of the most frequently immobilized proteins on the surface of carriers, including magnetic nanoparticles. This is because the drug-HSA interaction study is one of the basic pharmacokinetic parameters determined for drugs. In spite of many works describing the immobilization of HSA and the binding of active substances, research describing the influence of the used support on the effectiveness of immobilization is missing. There are also no reports about the effect of the support drying method on the effectiveness of protein immobilization. This paper examines the effect of both the method of functionalizing the polymer coating covering magnetic nanoparticles (MNPs), and the drying methods for the immobilization of HSA. Albumin was immobilized on three types of aminated chitosan-coated nanoparticles with a different content of amino groups long distanced from the surface Fe

Indexed as

Coated Materials, BiocompatibleImmobilized ProteinsMagnetite NanoparticlesSerum Albumin, HumanAdsorptionAminationChitosanHumansModels, MolecularModels, TheoreticalMolecular ConformationPolymersSolventsSpectroscopy, Fourier Transform InfraredChitosanCoated Materials, BiocompatibleImmobilized ProteinsMagnetite NanoparticlesPolymersSerum Albumin, HumanSolventsaminated chitosanHSAmagnetic nanoparticlesmolecular dynamics simulationsprotein immobilizationsolvent-free amination

Identifiers

PMID31109114
PMCPMC6572529
OpenAlexW2945320405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.