Evidence map›Paper›PMID 31109107›Full record

ArticleMolecules (Basel, Switzerland)2019

Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer.

Antonia Martin-Martin, Andrés Rivera-Dictter, Matías Muñoz-Uribe, Freddy López-Contreras, Jorge Pérez-Laines, Alfredo Molina-Berríos, Rodrigo López-Muñoz

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Antonia Martin-MartinInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. antoniamartinm94@gmail.com.
Andrés Rivera-DictterInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. ariveradictter@gmail.com.
Matías Muñoz-UribeInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. matias.munoz@uach.cl.
Freddy López-ContrerasInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. freddy.lopez@postgrado.uach.cl.
Jorge Pérez-LainesInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. jorgeperezlaines@gmail.com.
Alfredo Molina-BerríosInstituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago 8380492, Chile. aemolina@u.uchile.cl.
Rodrigo López-MuñozInstituto de Farmacología y Morfofisiología, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia 5090000, Chile. rodrigo.lopez@uach.cl.ORCID 0000-0003-1825-8563
Austral University of Chile · CLUniversity of Chile · CL

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico FONDECYT 1160807
6 · The paper itself

Abstract

Nitric oxide-releasing aspirins (NO-aspirins) are aspirin derivatives that are safer than the parent drug in the gastrointestinal context and have shown superior cytotoxic effects in several cancer models. Despite the rationale for their design, the influence of nitric oxide (NO

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAspirinCell Line, TumorCell MovementCell ProliferationCell SurvivalCyclooxygenase InhibitorsDinoprostoneDrug SynergismErlotinib HydrochlorideHumansLung NeoplasmsMolecular StructureNitric OxideNitro CompoundsAnti-Inflammatory Agents, Non-SteroidalAspirinCyclooxygenase InhibitorsDinoprostoneErlotinib HydrochlorideNCX 4040Nitric OxideNitro CompoundscyclooxygenaseerlotinibNCX4016NCX4040nitric oxidenon-small-cell lung cancerprostaglandin

Identifiers

PMID31109107
PMCPMC6572483
OpenAlexW2945494400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.