Evidence map›Paper›PMID 31109099›Full record

ReviewNutrients2019

Mechanisms Involved in the Relationship between Low Calcium Intake and High Blood Pressure.

Cecilia Villa-Etchegoyen, Mercedes Lombarte, Natalia Matamoros, José M Belizán, Gabriela Cormick

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 11 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 11 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
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  4. Calcium supplementation for people with overweight or obesity.The Cochrane database of systematic reviews · 2024
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  9. Calcium supplementation for prevention of primary hypertension.The Cochrane database of systematic reviews · 2022
    Pooled it
  10. Calcium supplementation for prevention of primary hypertension.The Cochrane database of systematic reviews · 2021
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  12. Trial
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Cecilia Villa-EtchegoyenLaboratory of Cardiovascular Surveillance of Drugs, Department of Toxicology and Pharmacology, School of Medicine, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Buenos Aires 1121, Argentina. c.villaetchegoyen@gmail.com.
Mercedes LombarteBone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe 3100, Argentina. mercedes_lombarte@yahoo.com.ar.
Natalia MatamorosInstituto de Desarrollo e Investigaciones Pediátricas "Prof. Dr. Fernando E. Viteri" Hospital de Niños "Sor María Ludovica de La Plata (IDIP), Ministerio de Salud/Comisión de Investigacines Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires 1900, Argentina. natymatamoros@gmail.com.
José M BelizánDepartment of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), Ciudad Autonoma de Buenos Aires, Buenos Aires 1414, Argentina. belizanj@gmail.com.
Gabriela CormickDepartment of Mother and Child Health Research, Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), Ciudad Autonoma de Buenos Aires, Buenos Aires 1414, Argentina. gabmick@yahoo.co.uk.ORCID 0000-0001-7958-7358
Consejo Nacional de Investigaciones Científicas y Técnicas · ARMinisterio de Salud · ARNational University of Rosario · ARUniversidad de Buenos Aires · AR

Funding

Bill and Melinda Gates Foundation OPP1190821
6 · The paper itself

Abstract

There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin-angiotensin-aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.

Indexed as

Blood PressureCalciumHumansHypertensionParathyroid GlandsParathyroid HormoneCalciumParathyroid Hormoneblood pressurecalcium intakeparathyroid functionrenin-angiotensin-aldosterone systemvitamin D

Identifiers

PMID31109099
PMCPMC6566648
OpenAlexW2946128670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.