ReviewNutrients2019
Maternal Omega-3 Nutrition, Placental Transfer and Fetal Brain Development in Gestational Diabetes and Preeclampsia.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials.Archives of gynecology and obstetrics · 2024Pooled it
- Association of circulating omega 3, 6 and 9 fatty acids with gestational diabetes mellitus: a systematic review.BMC endocrine disorders · 2021Pooled it
- Maternal diet and gestational diabetes mellitus modestly influence children's growth during their first 24 months.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Leptin-cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming.Experimental physiology · 2026Review
- Sex Differences in Combined Effects of Maternal Pre-Pregnancy BMI and OGTT Response Patterns on Early Neurodevelopment in Offspring: A Cohort Study.Journal of diabetes · 2026Article
- Early interventions for the prevention of preeclampsia in pregnant women at increased risk: a network meta-analysis.The Cochrane database of systematic reviews · 2026Article
- Elevated maternal testosterone induces sex-specific neurodevelopmental changes and ASD-related behavioral phenotypes in rat offspring.Pediatric research · 2026Article
- Gestational diabetes in the pregnant Omani population in relation to their fatty acid intake and levels.BMC pregnancy and childbirth · 2026Article
- DHA: Nutritional Programming During the First 1000 Days of Life.Nutrients · 2026Review
- The Role of Docosahexaenoic Acid in the Development of Preeclampsia and Perinatal Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- First-trimester triglyceride-glucose index and birth weight: a retrospective cohort mediation analysis of preterm birth and gestational complications.BMC pregnancy and childbirth · 2025Article
- Article
- The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System.Cellular and molecular neurobiology · 2025Review
- A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence.Nature metabolism · 2025Article
- Strict vegetarian diet and pregnancy outcomes: A systematic review and meta-analysis.Metabolism open · 2025Review
- Progress of Eastern Mediterranean Countries towards Meeting USDA Dietary Guidelines for Pregnant Women: A Focused Review.Current nutrition reports · 2025Review
- Effect of n-3 Polyunsaturated Fatty Acids Enriched Chicken Meat Consumption in Relation to Oxidative Stress Marker Levels in Young Healthy Individuals: A Randomized Double-Blind Study.Antioxidants (Basel, Switzerland) · 2025Article
- The association between gestational hypothyroidism in pregnant women with preeclampsia, maternal liver function indicators, and neonatal birth weight: a study in Chinese pregnant women.Frontiers in endocrinology · 2025Article
- Women's experiences of high-risk pregnancy care in resource constrained Cape Town communities.Health SA = SA Gesondheid · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Omega-3 fatty acids, particularly docosahexaenoic fatty acid (DHA), are widely recognized to impact fetal and infant neurodevelopment. The impact of DHA on brain development, and its inefficient synthesis from the essential alpha-linolenic acid (ALA), has led to recommended DHA intakes of 250-375 mg eicosapentaenoic acid + DHA/day for pregnant and lactating women by the Dietary Guidelines for Americans. Despite these recommendations, the intake of omega-3s in women of child-bearing age in the US remains very low. The low maternal status of DHA prior to pregnancy could impair fetal neurodevelopment. This review focuses on maternal omega-3 status in conditions of gestational diabetes mellitus (GDM) and preeclampsia, and the subsequent impact on placental transfer and cord blood concentration of omega-3s. Both GDM and preeclampsia are associated with altered maternal omega-3 status, altered placental omega-3 metabolism, reduced cord blood omega-3 levels and have an impact on neurodevelopment in the infant and on brain health later in life. These findings indicate lower DHA exposure of the developing baby may be driven by lower placental transfer in both conditions. Thus, determining approaches which facilitate increased delivery of DHA during pregnancy and early development might positively impact brain development in infants born to mothers with these diseases.
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