Evidence map›Paper›PMID 31109015›Full record

ArticleMolecules (Basel, Switzerland)2019

Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H

Wei Guan, Yan Liu, Yuan Liu, Qi Wang, Hong-Liang Ye, Yan-Gang Cheng, Hai-Xue Kuang, Xi-Cheng Jiang, Bing-You Yang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Evaluation of the Cardioprotective Potential ofProtein and peptide letters · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021
    Article
  7. Proteomic Profiling ofMolecules (Basel, Switzerland) · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei GuanKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. myguanwei1234@yeah.net.
Yan LiuKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. flyliuyuan@163.com.
Yuan LiuKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. flyliuyuan@163.com.
Qi WangDepartment of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150036, China. mydearmumu@163.com.
Hong-Liang YeKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. 15645183280@163.com.
Yan-Gang ChengKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. chengyg1992@163.com.
Hai-Xue KuangKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. hxkuang@yahoo.com.
Xi-Cheng JiangKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. jiangxicheng5303@163.com.
Bing-You YangKey Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. ybywater@163.com.
Heilongjiang University of Chinese Medicine · CNHarbin Medical University · CN

Funding

National Basic Research Program of China (973 Program) 2013CB531801University Nursing Program for Yong Scholars with Creative Talents in Heilongjiang Province UNPYSCT-2017221
6 · The paper itself

Abstract

Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide. Mangiferin is a natural glucosylxanthone with antioxidant and anti-inflammatory properties, which has been confirmed to protect cardiac cells from myocardial infarction and myocardial ischemia reperfusion injury (MIRI); however, the underlying mechanism is still unclear. As oxidative stress is a major pathogenesis of MIRI, an H9C2 cell injury induced by hydrogen peroxide (H

Indexed as

AnimalsCardiotonic AgentsCell LineCitric Acid CycleGene Expression RegulationGlycolysisHydrogen PeroxideMyocytes, CardiacOxidative StressProteomicsRatsXanthonesCardiotonic AgentsHydrogen PeroxidemangiferinXanthonesH9C2iTRAQmangiferinmyocardial ischemia and reperfusion injuryoxidative stressproteomics

Identifiers

PMID31109015
PMCPMC6572523
OpenAlexW2945235910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.