Evidence map›Paper›PMID 31108950›Full record

ArticleGenes2019

Identification and Validation of Novel Reference Genes in Acute Lymphoblastic Leukemia for Droplet Digital PCR.

Vanessa Villegas-Ruíz, Karina Olmos-Valdez, Kattia Alejandra Castro-López, Victoria Estefanía Saucedo-Tepanecatl, Josselen Carina Ramírez-Chiquito, Eleazar Israel Pérez-López, Isabel Medina-Vera, Sergio Juárez-Méndez

Open access · goldAbstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  8. Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2020
    Review
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vanessa Villegas-RuízExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. vanessavillegasruiz@yahoo.com.mx.ORCID 0000-0002-5441-2612
Karina Olmos-ValdezExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. kary_230794@hotmail.com.
Kattia Alejandra Castro-LópezExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. kattia.castrolpz@gmail.com.
Victoria Estefanía Saucedo-TepanecatlExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. saucedo9116@hotmail.com.
Josselen Carina Ramírez-ChiquitoExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. carina-rc@outlook.com.
Eleazar Israel Pérez-LópezExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. eleazarisraelp@yahoo.com.mx.
Isabel Medina-VeraResearch Methodology Department, National Institute of Pediatrics, Mexico City 04530, Mexico. isabelj.medinav@gmail.com.ORCID 0000-0003-4027-2329
Sergio Juárez-MéndezExperimental Oncology Laboratory, Research Department, National Institute of Pediatrics, Mexico City 04530, Mexico. sjuarezm@pediatria.gob.mx.ORCID 0000-0002-3269-329X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Droplet digital PCR is the most robust method for absolute nucleic acid quantification. However, RNA is a very versatile molecule and its abundance is tissue-dependent. RNA quantification is dependent on a reference control to estimate the abundance. Additionally, in cancer, many cellular processes are deregulated which consequently affects the gene expression profiles. In this work, we performed microarray data mining of different childhood cancers and healthy controls. We selected four genes that showed no gene expression variations (

Indexed as

Adaptor Proteins, Signal TransducingAlkyl and Aryl TransferasesAutophagy-Related ProteinsCell Line, TumorGene Expression ProfilingGenes, EssentialHumansPolymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-LymphomaProteasome Endopeptidase ComplexReference StandardsRNATranscriptomeAdaptor Proteins, Signal TransducingAlkyl and Aryl TransferasesAutophagy-Related Proteinsgeranylgeranyltransferase type-IProteasome Endopeptidase ComplexPSMB6 protein, humanRNAUBQLN2 protein, humandroplet digital PCRgene expressionleukemiareferences genes

Identifiers

PMID31108950
PMCPMC6562415
OpenAlexW2945924680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.