ReviewInternational journal of molecular sciences2019
The Enterochromaffin-like [ECL] Cell-Central in Gastric Physiology and Pathology.
Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Beyond Type 1 Diabetes: Autoimmune Gastritis-Driven Multisystem Disease in Autoimmune Polyglandular Syndrome Type 3.Cureus · 2026Article
- Perspectives on gastric cancer: the central role of gastrin in carcinogenesis byFrontiers in oncology · 2026Review
- Sleeve gastrectomy reveals the plasticity of the human gastric epithelium.Nature communications · 2025Article
- Article
- Correctly identifying the cells of origin is essential for tailoring treatment and understanding the emergence of cancer stem cells and late metastases.Frontiers in oncology · 2024Review
- Proton-pump inhibitor-induced bone loss is preventable by concomitant use of a long-acting somatostatin analogue.Iranian journal of basic medical sciences · 2024Article
- Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions.Heliyon · 2023Review
- Inflammation and Digestive Cancer.International journal of molecular sciences · 2023Review
- LC-ESI-MS phenolic contents assessment, antioxidant, and protective ability ofToxicology research · 2023Article
- The central role of gastrin in gastric cancer.Frontiers in oncology · 2023Review
- Time to Classify Tumours of the Stomach and the Kidneys According to Cell of Origin.International journal of molecular sciences · 2021Review
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- Review
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- Towards Understanding of Gastric Cancer Based upon Physiological Role of Gastrin and ECL Cells.Cancers · 2020Review
- Limited Diagnostic Utility of Chromogranin A Measurements in Workup of Neuroendocrine Tumors.Diagnostics (Basel, Switzerland) · 2020Article
- Article
- Proton Pump Inhibitor Use, Hypergastrinemia, and Gastric Carcinoids-What Is the Relationship?International journal of molecular sciences · 2020Review
- CHRONIC USE OF PROTON PUMP INHIBITORS AND THE QUANTITY OF G, D, AND ECL CELLS IN THE STOMACH.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies on the regulation of gastric and pancreatic secretion began more than 100 years ago. Secretin was the first hormone postulated to exist, initiating the field of endocrinology. Gastrin produced in the antral mucosa was the second postulated hormone, and together with histamine and acetylcholine, represent the three major gastric acid secretagogues known since 1920. For a long time, the mast cell was the only recognized histamine-producing cell in the oxyntic mucosa and, in the mid-1980s, the ECL cell was recognized as the cell producing histamine, taking part in the regulation of gastric acid secretion.
methodsThis review is based upon literature research and personal knowledge.
resultsThe ECL cell carries the gastrin receptor, and gastrin regulates its function (histamine release) as well as proliferation. Long-term hypergastrinemia results in gastric neoplasia of variable malignancies, implying that gastric hypoacidity resulting in increased gastrin release will induce gastric neoplasia, including gastric cancer.
conclusionsThe trophic effect of gastrin on the ECL cell has implications to the treatment with inhibitors of acid secretion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.