ReviewSeminars in thrombosis and hemostasis2019
Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review.
Review in Seminars in thrombosis and hemostasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Thromboelastography-Based Risk-Stratified Transfusion Strategy in Acute Stanford Type A Aortic Dissection: A Predictive Model and Prospective Validation.Journal of clinical medicine · 2026Article
- Biochemical and haemostatic variables associated with metastasis in dogs with carcinoma or sarcoma.The Journal of small animal practice · 2026Article
- Hypercoagulable state and effect of low-molecular-weight heparin prophylaxis on coagulation after lung cancer resection: results from thrombo-elastography.General thoracic and cardiovascular surgery · 2025Article
- Prediction model of gastrointestinal tumor malignancy based on coagulation indicators such as TEG and neural networks.Frontiers in immunology · 2025Article
- Cancer-Associated Thrombosis: Pathophysiology, Laboratory Assessment, and Current Guidelines.Cancers · 2024Review
- Features of thromboelastogram in populations exposed to or transferring from high altitude.Heliyon · 2024Article
- Global hemostasis assays in acute myeloid leukemia: results of an observational prospective study.Blood transfusion = Trasfusione del sangue · 2024Observational
- Construction of nomogram model for risk of venous thromboembolism after spine surgery based on thromboelastography and coagulation indices.Frontiers in medicine · 2024Article
- Analyzing venous thromboembolism risk in malignant tumors: thromboelastogram and coagulation factors study.Biomarkers in medicine · 2024Article
- Thromboelastography (TEG) parameters as potential predictors of malignancy and tumor progression in colorectal cancer.World journal of surgical oncology · 2023Article
- Fibrinolysis shutdown and elevated D-dimer levels have high prognostic capacity for postoperative thromboembolic complications in patients with bone tumors.Journal of thrombosis and thrombolysis · 2023Observational
- Association between PT, PT-INR, and in-hospital mortality in critically ill patients with tumors: A retrospective cohort study.Frontiers in public health · 2023Article
- SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock.Frontiers in physiology · 2023Review
- "TEG" talks: technology worth spreading?Research and practice in thrombosis and haemostasis · 2023Article
- Evaluation of Haemostasis in Dogs Affected by Resectable Malignancy.Animals : an open access journal from MDPI · 2022Article
- The Hypercoagulable Profile of Patients with Bone Tumors: A Pilot Observational Study Using Rotational Thromboelastometry.Cancers · 2022Article
- The Need for Individualized Risk Assessment in Cardiovascular Disease.Journal of personalized medicine · 2022Review
- Use of Thromboelastography and Rotational Thromboelastometry in Otolaryngology: A Narrative Review.Journal of clinical medicine · 2022Review
- Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices.Journal of clinical medicine · 2022Review
- Machine Learning to Calculate Heparin Dose in COVID-19 Patients with Active Cancer.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 1 country.
Funding
Abstract
The relationship between malignancy and coagulopathy is one that is well documented yet incompletely understood. Clinicians have attempted to quantify the hypercoagulable state produced in various malignancies using common coagulation tests such as prothrombin time, activated partial thromboplastin time, and platelet count; however, due to these tests' focus on individual aspects of coagulation during one specific time point, they have failed to provide clinicians the complete picture of malignancy-associated coagulopathy (MAC). Viscoelastic tests (VETs), such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM), are whole blood analyses that have the advantage of providing information related to the cumulative effects of plasma clotting factors, platelets, leukocytes, and red cells during all stages of the coagulation and fibrinolytic processes. VETs have gained popularity in the care of trauma patients to objectively measure trauma-induced coagulopathy (TIC), but the utility of VETs remains yet unrealized in many other medical specialties. The authors discuss the similarities and differences between TIC and MAC, and propose a mechanism for the hypercoagulable state of MAC that revolves around the thrombomodulin-thrombin complex as it switches between activating the protein C anticoagulation pathway or the thrombin activatable fibrinolysis inhibitor coagulation pathway. Additionally, they review the current literature on the use of TEG and ROTEM in patients with various malignancies. Although limited research is currently available, early results demonstrate the utility of both TEG and ROTEM in the prediction of hypercoagulable states and thromboembolic complications in oncologic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.