Evidence map›Paper›PMID 31108498›Full record

ArticleNature2019

Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.

Sandip Kaledhonkar, Ziao Fu, Kelvin Caban, Wen Li, Bo Chen, Ming Sun, Ruben L Gonzalez, Joachim Frank

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 149 citations in OpenAlex.

  1. eLife · 2026
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  10. Mechanistic insights intobioRxiv : the preprint server for biology · 2026
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sandip Kaledhonkar *Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY, USA.
Ziao Fu *Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, New York, NY, USA.
Kelvin Caban *Department of Chemistry, Columbia University, New York, NY, USA.
Wen LiDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY, USA.
Bo ChenDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY, USA.
Ming SunDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, NY, USA. rlg2118@columbia.edu.
Joachim FrankDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY, USA. jf2192@cumc.columbia.edu.
Columbia University · US

Funding

STRUCTURE ANALYSIS OF MACROMOLECULAR ASSEMBLIESR01GM029169 · NIGMS · WADSWORTH CENTER · PI FRANK, JOACHIM · 1985 to 2019
$6.1M
Time-resolved Cryo-EM of Short-lived States in Eukaryotic TranslationR01GM055440 · NIGMS · WADSWORTH CENTER · PI FRANK, JOACHIM · 1997 to 2020
$5.1M
The Structural Dynamics of Translation InitiationR01GM084288 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2009 to 2022
$4.4M
STRUCTURAL ANALYSIS OF MACROMOLECULAR ASSEMBLYR37GM029169 · NIGMS · WADSWORTH CENTER · PI FRANK, JOACHIM · 1997 to 2006
$2.8M
NIGMS NIH HHS R01 GM029169NIGMS NIH HHS R01 GM055440NIGMS NIH HHS R01 GM084288NIGMS NIH HHS R37 GM029169NIH HHS GM 29169
6 · The paper itself

Abstract

The initiation of bacterial translation involves the tightly regulated joining of the 50S ribosomal subunit to an initiator transfer RNA (fMet-tRNA

Indexed as

Cryoelectron MicroscopyPeptide Chain Initiation, TranslationalEscherichia coliPeptide Chain Elongation, TranslationalProtein ConformationRibosomesRibosome Subunits, Large, BacterialRibosome Subunits, Small, BacterialTime Factors

Identifiers

PMID31108498
PMCPMC7060745
OpenAlexW2944873741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.