Evidence map›Paper›PMID 31108370›Full record

ArticleNeoplasia (New York, N.Y.)2019

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.

Shuaiyi Chen, Xin Yang, Miao Yu, Zhe Wang, Boya Liu, Minghui Liu, Lu Liu, Mengmeng Ren, Hao Qi, Junhua Zou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. β-Nicotinamide mononucleotide blocks UVB-induced collagen reduction via regulation of ROS/MAPK/AP-1 and stimulation of mitochondrial proline biosynthesis.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  7. Review
  8. Roles of SIRT3 in aging and aging-related diseases.International journal of biological sciences · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Shuaiyi ChenDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Xin YangDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Miao YuDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Zhe WangDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Boya LiuDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Minghui LiuDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Lu LiuDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Mengmeng RenDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Hao QiDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Junhua ZouDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China.
Ivana VucenikDepartment of Medical and Research Technology, University of Maryland, Baltimore, MD 21201, USA.
Wei-Guo ZhuDepartment of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China.
Jianyuan LuoDepartment of Medical Genetics, Peking University Health Science Center, Beijing, 100191, China; Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Biophysics, Peking University Health Science Center, Beijing 100191, China. Electronic address: luojianyuan@bjmu.edu.cn.
Peking University · CNShenzhen University · CNUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SIRT3 is a major mitochondrial deacetylase, which regulates various metabolic pathways by deacetylation; however, the effect of SIRT3 on proline metabolism is not reported. Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD

Indexed as

AcetylationCell Proliferationdelta-1-Pyrroline-5-Carboxylate ReductaseHumansMCF-7 CellsMitochondriaNeoplasmsPeptide FragmentsProlinePyrroline Carboxylate ReductasesSialoglycoproteinsSirtuin 3bone sialoprotein (35-62), humandelta-1-Pyrroline-5-Carboxylate ReductasePeptide FragmentsProlinePyrroline Carboxylate ReductasesSialoglycoproteinsSIRT3 protein, humanSirtuin 3

Identifiers

PMID31108370
PMCPMC6526305
OpenAlexW2945072981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.