Evidence map›Paper›PMID 31108277›Full record

GuidelineRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2019

ESTRO ACROP consensus guideline for target volume delineation in the setting of postmastectomy radiation therapy after implant-based immediate reconstruction for early stage breast cancer.

Orit Kaidar-Person, Birgitte Vrou Offersen, Sandra Hol, Meritxell Arenas, Cynthia Aristei, Celine Bourgier, Maria Joao Cardoso, Boon Chua, Charlotte E Coles, Tine Engberg Damsgaard and 17 more

Registry-linked trialOpen access · greenAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830083 (Hypofractionated Radiation Fractionation in Breast Cancer Patients With Implant-Based Reconstruction), which is not on this map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830083 narecruitingnot on this mapstarted 2025, after this paper: background citation

Hypofractionated Radiation Fractionation in Breast Cancer Patients With Implant-Based Reconstruction

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2025 to 2033Enrolled840ConditionsBreast CancerArmsHypofractionated Radiation Therapy, Conventional fraction radiotherapy
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Review
  4. Review
  5. Breast cancer related lymphedema and shoulder mobility following radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Practical considerations for handling implants in proton therapy.Journal of applied clinical medical physics · 2025
    Article
  10. In Regard to Hsu et al.Advances in radiation oncology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Implant-based reconstruction and adjuvant radiotherapy in breast cancer patients-current status and DEGRO recommendations.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Review
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 16 countries.

Orit Kaidar-PersonOncology Institute, Radiation Oncology Unit, Rambam Medical Center, Haifa, Israel. Electronic address: o_person@rambam.health.gov.il.
Birgitte Vrou OffersenDepartment of Experimental Clinical Oncology, Danish Center for Particle Therapy, Department of Oncology, Aarhus University Hospital, Denmark.
Sandra HolDepartment of Radiation Oncology, Institute Verbeeten, Tilburg, the Netherlands.
Meritxell ArenasDepartment of Radiation Oncology, Hospital Universitari Sant Joan de Reus, University Rovira i Virgili, Spain.
Cynthia AristeiRadiation Oncology Section, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Italy.
Celine BourgierDepartment of Radiation Oncology, ICM - Val d'Aurelle, INSERM U1194, IRCM; Montpellier University, Montpellier, France.
Maria Joao CardosoBreast Unit, Champalimaud Foundation, and Nova Medical School, Lisbon, Portugal.
Boon ChuaFaculty of Medicine, The University of New South Wales, UNSW Sydney, NSW, Australia.
Charlotte E ColesCambridge University, Department of Oncology, United Kingdom.
Tine Engberg DamsgaardDepartment of Plastic and Breast Surgery, Aarhus University Hospital, Denmark.
Dorota GabrysDepartment of Radiation Oncology, Maria Sklodowska Curie Memorial Cancer Centre, Gliwice, Poland.
Reshma JagsiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, USA.
Rachel JimenezDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, USA.
Anna M KirbyDepartment of Radiotherapy, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, UK.
Carine KirkoveDepartment of Radiation Oncology, University Hospital St-Luc, Brussels, Belgium.
Youlia KirovaDepartment of Radiation Oncology, Institut Curie, Paris, France.
Vassilis KoulouliasNational and Kapodistrian University of Athens, Medical School, 2nd Dpt of Radiology, Radiotherapy Unit, Athens, Greece.
Tanja MarinkoDepartment of Radiation Oncology, Institute of Oncology Ljubljana, Slovenia.
Icro MeattiniDepartment of Biomedical, Experimental, and Clinical Sciences, University of Florence, Italy, Radiation Oncology Unit - Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Ingvil MjaalandDepartment of Oncology & Radiotherapy, Stavanger University Hospital, Norway.
Gustavo Nader MartaDepartment of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil; Department of Radiology and Oncology, Division of Radiation Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), Faculdade de Medicina da Universidade de São Paulo, Brazil.
Petra Witt NystromThe Skandion Clinic, Uppsala, Sweden and Danish Center for Particle Therapy, Aarhus, Denmark.
Elzbieta SenkusDepartment of Oncology & Radiotherapy, Medical University of Gdańsk, Poland.
Tanja SkyttäDepartment of Oncology, Tampere University Hospital, Finland.
Tove F TvedskovDept. of Breast Surgery, Herlev Hospital, Copenhagen, Denmark.
Karolien VerhoevenGROW School for Oncology and Developmental Biology, Department of Radiation Oncology, Maastricht University Medical Centre, Netherlands.
Philip PoortmansDepartment of Radiation Oncology, Institut Curie, and Paris Sciences & Lettres University, Paris, France.
Aarhus University Hospital · DKInstitut Curie · FRAzienda Ospedaliero-Universitaria Careggi · ITCentre for Cosmology and Particle Physics Phenomenology · DKChampalimaud Foundation · PTGdańsk Medical University · PLHerlev Hospital · DKHospital Universitari Sant Joan de Reus · ESInserm · FRInstitute of Oncology Ljubljana · SIInstituut Verbeeten · NLMaastricht University Medical Centre · NLMassachusetts General Hospital · USNational and Kapodistrian University of Athens · GRRambam Health Care Campus · ILRoyal Marsden NHS Foundation Trust · GBStavanger University Hospital · NOTampere University Hospital · FIThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversidade de São Paulo · BR

Funding

Cancer Research UK 19727
6 · The paper itself

Abstract

Immediate breast reconstruction (IBR) rates after mastectomy are increasing. Postmastectomy radiation therapy (PMRT) contouring guidelines for target volumes in the setting of IBR are lacking. Therefore, many patients who have had IBR receive PMRT to target volumes similar to conventional simulator-based whole breast irradiation. The aim of this paper is to describe delineation guidelines for PMRT after implant-based IBR based on a thorough understanding of the surgical procedures, disease stage, patterns of recurrence and radiation techniques. They are based on a consensus endorsed by a global multidisciplinary group of breast cancer experts.

Indexed as

Breast ImplantationBreast NeoplasmsConsensusFemaleHumansMammaplastyMastectomyNeoplasm Recurrence, LocalNeoplasm StagingRadiotherapy, AdjuvantRadiotherapy Planning, Computer-AssistedBreast cancerGuidelinesImmediate reconstructionImplantMastectomyRadiation therapy

Identifiers

PMID31108277
OpenAlexW2945616604

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.