Evidence map›Paper›PMID 31108129›Full record

ArticleNeuroscience letters2019

Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder.

James J Prisciandaro, Joseph P Schacht, Andrew P Prescot, Helena M Brenner, Perry F Renshaw, Truman R Brown, Raymond F Anton

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

James J PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Medical University of SC, Charleston, SC, United States. Electronic address: priscian@musc.edu.
Joseph P SchachtDepartment of Psychiatry and Behavioral Sciences, Medical University of SC, Charleston, SC, United States.
Andrew P PrescotDepartment of Radiology, University of Utah, Salt Lake City, UT, United States.
Helena M BrennerDepartment of Psychiatry and Behavioral Sciences, Medical University of SC, Charleston, SC, United States.
Perry F RenshawDepartment of Psychiatry, University of Utah, Salt Lake City, UT, United States.
Truman R BrownDepartment of Radiology, Medical University of SC, Charleston, SC, United States.
Raymond F AntonDepartment of Psychiatry and Behavioral Sciences, Medical University of SC, Charleston, SC, United States.
Medical University of South Carolina · USUniversity of Utah · US

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HOWARD C. BECKER · 1996 to 2026
$46.8M
Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7M
Neuroimaging mechanisms of overlap between alcoholism and bipolar disorderK23AA020842 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2012 to 2016
$835k
Neural Connectivity and the Transition to Alcohol DependenceR00AA021419 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCHACHT, JOSEPH P. · 2015 to 2017
$747k
NIAAA NIH HHS K23 AA020842NIAAA NIH HHS P50 AA010761NIAAA NIH HHS R00 AA021419NIAAA NIH HHS R01 AA025365
6 · The paper itself

Abstract

Although the neurotransmitters/modulators glutamate and, more recently, glycine have been implicated in the development and maintenance of Alcohol Use Disorder (AUD) in preclinical research, human proton magnetic resonance spectroscopy (

Indexed as

AdultAlcoholismBinge DrinkingFemaleFrontal LobeGlutamic AcidGlycineHumansMaleProton Magnetic Resonance SpectroscopyYoung AdultGlutamic AcidGlycineAlcohol use disorderGlutamateGlycineHeavy drinkingProton magnetic resonance spectroscopy

Identifiers

PMID31108129
PMCPMC6621545
OpenAlexW2946145655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.