ArticlePediatrics international : official journal of the Japan Pediatric Society2019
Pediatric intensive care unit admission due to respiratory syncytial virus: Retrospective multicenter study.
Article in Pediatrics international : official journal of the Japan Pediatric Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Children born preterm admitted to paediatric intensive care for bronchiolitis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Development and internal validation of a clinical prediction model for septic shock in pediatric respiratory syncytial virus bronchiolitis based on routine blood biomarkers and concomitant fungal infection.Frontiers in cellular and infection microbiology · 2026Trial
- Sleep Characteristics of Parents of Children in the Paediatric Intensive Care Unit: A Pilot Observational Study.Nursing in critical care · 2026Observational
- Contributors to perceived workload strain in the pediatric intensive care unit.Intensive care medicine. Paediatric and neonatal · 2026Article
- Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis.EClinicalMedicine · 2025Review
- Hospital-based cross-sectional study on the clinical characteristics of children with severe acute respiratory infections in Hungary.BMC infectious diseases · 2024Article
- Respiratory Syncytial Virus Infections in Pediatric Intensive Care: Association of Sociodemographic Data and Clinical Outcomes with Viral and Bacterial Co-infections.Turkish archives of pediatrics · 2024Article
- Respiratory Syncytial Virus Immunoprophylaxis with Palivizumab: 12-Year Observational Study of Usage and Outcomes in Canada.American journal of perinatology · 2022Observational
- Trends in US Pediatric Hospital Admissions in 2020 Compared With the Decade Before the COVID-19 Pandemic.JAMA network open · 2021Article
- Optimizing risk factors to guide COST-effective use of palivizumab in KOREAN infants.Pediatrics international : official journal of the Japan Pediatric SocietyArticle
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundWe investigated the characteristics and clinical outcomes of respiratory syncytial virus (RSV)-related pediatric intensive care unit (PICU) hospitalization and assessed the palivizumab (PZ) prophylaxis eligibility according to different guidelines from Korea, EU, and USA.
methodsIn this multicenter study, children <18 years of age hospitalized in six PICU from different hospitals due to severe RSV infection between September 2008 and March 2013 were included. A retrospective chart review was performed.
resultsA total of 92 patients were identified. The median length of PICU stay was 6 days (range, 1-154 days) and median PICU care cost was USD2,741 (range, USD556-98 243). Of 62 patients who were <2 years old at the beginning of the RSV season, 33 (53.2%) were high-risk patients for severe RSV infection. Hemodynamically significant congenital heart disease (22.6%) was the most common risk factor, followed by chronic lung disease (11.3%), neuromuscular disease or congenital abnormality of the airway (NMD/CAA) (11.3%), and prematurity (8.1%). The percentage of patients eligible for PZ prophylaxis ranged from 38.7% to 48.4% based on the guidelines, but only two (2.2%) received PZ ≤30 days prior to PICU admission. The median duration of mechanical ventilation was longer in children with NDM/CAA than in those without risk factors (26 days; range, 24-139 days vs 6 days, range, 2-68 days, P = 0.033). RSV-attributable mortality was 5.4%.
conclusionsChildren <2 years old with already well-known high risks represent a significant proportion of RSV-related PICU admissions. Increasing of the compliance for PZ prophylaxis practice among physicians is needed. Further studies are needed to investigate the burden of RSV infection in patients hospitalized in PICU, including children with NMD/CAA.
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