ReviewClinical and experimental immunology2019
Metabolism at the centre of the host-microbe relationship.
Review in Clinical and experimental immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Effects of exercise and physical activity on gut microbiota composition and function in older adults: a systematic review.BMC geriatrics · 2023Pooled it
- Effects of selection on production parameters and intestinal microbiota in heritage and modern broiler chickens.Journal of animal science and biotechnology · 2026Article
- Regulation of interbacterial interactions betweenbioRxiv : the preprint server for biology · 2026Article
- TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis.Nature communications · 2026Article
- Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities.International journal of molecular sciences · 2025Review
- Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites.Nature communications · 2025Article
- Characterizing probiotic profiles using genomic and metabolomic insights into chicken cecum-derivedFrontiers in microbiology · 2025Article
- Hyperoxia as a driver of gut dysbiosis.Frontiers in microbiology · 2025Review
- Development and validation of a nomogram for predicting immune-related pneumonitis after sintilimab treatment.Cancer medicine · 2024Article
- Screening for probiotic properties and potential immunogenic effects of lactobacilli strains isolated from various food products.Frontiers in microbiology · 2024Article
- East meets west: integrating Yin-Yang theory with immunology teaching.Frontiers in immunology · 2024Review
- Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression.G3 (Bethesda, Md.) · 2023Article
- Article
- Microbiome influencers of checkpoint blockade-associated toxicity.The Journal of experimental medicine · 2023Article
- Effect of Caging onMicroorganisms · 2022Article
- The role of LPS and CpG in the farm effect against allergies, and beyond.Allergologie select · 2022Review
- Integrated metabolic and microbial analysis reveals host-microbial interactions in IgE-mediated childhood asthma.Scientific reports · 2021Article
- Maternal gut microbiome regulates immunity to RSV infection in offspring.The Journal of experimental medicine · 2021Article
- The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer.Annals of translational medicine · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Maintaining homoeostatic host-microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. However, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host-microbe relationship. It will look at the central role of epithelial metabolism in shaping the gut microbiota, how microbial metabolites influence the epithelium and the mucosal and peripheral immune system, and how the immune system shapes microbial composition and metabolism. Finally, this review will look at how metabolites are involved in cross-talk between different members of the microbiota and their role during infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.