ArticlePloS one2019
Chronic pain in adults with sickle cell disease is associated with alterations in functional connectivity of the brain.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Preliminary Benefits of In-Home Virtual Reality for Chronic Pain in Sickle Cell Disease: Pilot Randomized Trial.Biomedicines · 2026Article
- Suzetrigine for Vaso-Occlusive Pain in Sickle Cell Disease: A Three-Patient Case Series.Orthopedic reviews · 2026Article
- Brain networks activated when aggravating baseline chronic pain of an individual with new daily persistent headache: a case study.BMC neurology · 2025Article
- Investigating Disruptions in Information Flow due to Sickle Cell Disease Using Granger Causality.Human brain mapping · 2025Article
- Novel identifications of cerebral hemodynamics using BOLD fMRI in patients with sickle cell disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- ΔThe Journal of pharmacology and experimental therapeutics · 2024Article
- Increased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study.Brain topography · 2024Article
- Feasibility, Acceptability, and Efficacy of Home-Based Transcranial Direct Current Stimulation on Pain in Older Adults with Alzheimer's Disease and Related Dementias: A Randomized Sham-Controlled Pilot Clinical Trial.Journal of clinical medicine · 2023Article
- The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Article
- Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022Article
- Sickle cell disease chronic joint pain: Clinical assessment based on maladaptive central nervous system plasticity.Frontiers in medicine · 2022Review
- Implementation of Individualized Pain Care Plans Decreases Length of Stay and Hospital Admission Rates for High Utilizing Adults with Sickle Cell Disease.Pain medicine (Malden, Mass.) · 2021Article
- MRI detection of brain abnormality in sickle cell disease.Expert review of hematology · 2021Article
- Network Analysis of Induced Neural Plasticity Post-Acceptance and Commitment Therapy for Chronic Pain.Brain sciences · 2020Article
- Neuropathic pain in sickle cell disease: measurement and management.Hematology. American Society of Hematology. Education Program · 2020Review
- Functional Connectivity Decreases with Metabolic Stress in Sickle Cell Disease.Annals of neurology · 2020Article
- The controversial role of red cell transfusions for sickle cell pain.Current opinion in hematology · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Chronic pain affects 50% of adults with sickle cell disease (SCD). Although central sensitization is thought to contribute to the pathogenesis of this chronic pain, no studies have examined differences in functional connectivity of the brain between patients with SCD with and without chronic pain. We performed an observational cohort study using resting-state functional MRI (rsfMRI) of the brain on adults with SCD with and without chronic pain. We tested the hypothesis that, compared to those without chronic pain, those with chronic pain would have differences in functional connectivity between the periaqueductal grey (PAG) and other regions of the brain. Twenty-two adults with SCD, 15 with chronic pain and 7 without chronic pain, as well as 10 African-American controls, underwent rsfMRI of the brain. When SCD patients with chronic pain were compared to those without chronic pain, significant differences in connectivity were noted between the PAG and 9 regions of the brain, including several in the default mode network, a network involved in introspection that has been implicated in other chronic pain syndromes. Changes in functional connectivity between patients with SCD with and without chronic pain suggest a mechanism for chronic pain that involves neuro-plastic changes to the brain.
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