ArticlePloS one2019
Influence of own mother's milk and different proportions of formula on intestinal microbiota of very preterm newborns.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Gut microbiota development in very preterm infants following fortification of human milk.mSystems · 2025Trial
- Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome.Cell reports. Medicine · 2022Trial
- Gut microbiota in necrotizing enterocolitis: a bibliometric and visualization analysis.Pediatric research · 2026Review
- Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate.Pediatric research · 2025Review
- Analysis of risk factors and establishment of predictive models for neonatal necrotizing enterocolitis: a retrospective study.Italian journal of pediatrics · 2025Article
- Effects of breast-fed infants-derivediScience · 2024Article
- Maternal-Foetal/Infant Interactions-Gut Microbiota and Immune Health.Biomedicines · 2024Review
- Maternal-fetal-neonatal microbiome and outcomes associated with prematurity.BMC pediatrics · 2024Article
- Noninvasive Fecal Cytokine and Microbiota Profiles Predict Commencement of Necrotizing Enterocolitis in a Proof-of-Concept Study.Gastro hep advances · 2023Article
- Increasing early exposure to mother's own milk in premature newborns.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Emerging trends and focus of human gastrointestinal microbiome research from 2010-2021: a visualized study.Journal of translational medicine · 2021Review
- Early Enteral Feeding in Preterm Infants: A Narrative Review of the Nutritional, Metabolic, and Developmental Benefits.Nutrients · 2021Review
- The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota.Microorganisms · 2021Article
- New Insights Into Microbiota Modulation-Based Nutritional Interventions for Neurodevelopmental Outcomes in Preterm Infants.Frontiers in microbiology · 2021Review
- The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?Frontiers in cellular and infection microbiology · 2021Review
- Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health.Nutrients · 2020Review
- Effect of Different Milk Diet on the Level of Fecal Calprotectin in Very Preterm Infants.Frontiers in pediatrics · 2020Article
- Differences in Compositions of Gut Bacterial Populations and Bacteriophages in 5-11 Year-Olds Born Preterm Compared to Full Term.Frontiers in cellular and infection microbiology · 2020Article
- Observational
- The challenges of neonatal sepsis management.Jornal de pediatriaReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the differences in preterm infants' stool microbiota considering the use of exclusive own mother's milk and formula in different proportions in the first 28 days of life.
methodsThe study included newborns with GA ≤ 32 weeks divided in 5 group according the feeding regimen: 7 exclusive own mother's milk, 8 exclusive preterm formula, 16 mixed feeding with >70% own mother's milk, 16 mixed feeding with >70% preterm formula, and 15 mixed 50% own mother's milk and preterm formula. Exclusion criteria: congenital infections, congenital malformations and newborns of drug addicted mothers. Stools were collected weekly during the first 28 days. Microbial DNA extraction, 16S rRNA amplification and sequencing were performed.
resultsAll groups were similar in perinatal and neonatal data. There were significant differences in microbial community among treatments. Approximately 37% of the variation in distance between microbial communities was explained by use of exclusive own mother´s milk only compared to other diets. The diet composed by exclusive own mother´s milk allowed for greater microbial richness (average of 85 OTUs) while diets based on preferably formula, exclusive formula, preferably maternal milk, and mixed of formula and maternal milk presented an average of 9, 29, 23, and 25 OTUs respectively. The mean proportion of the genus Escherichia and Clostridium was always greater in those containing formula than in the those with maternal milk only.
conclusionsFecal microbiota in the neonatal period of preterm infants fed with exclusive own mother's milk presented increased richness and differences in microbial composition from those fed with different proportions of formula.
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