ArticlePLoS neglected tropical diseases2019
Characterization of a yeast interfering RNA larvicide with a target site conserved in the synaptotagmin gene of multiple disease vector mosquitoes.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control.Parasites & vectors · 2025Article
- Silencing theInsects · 2025Article
- Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers.Scientific reports · 2024Article
- Key gene modules and hub genes associated with pyrethroid and organophosphate resistance in Anopheles mosquitoes: a systems biology approach.BMC genomics · 2024Article
- Challenges of Robust RNAi-Mediated Gene Silencing inInternational journal of molecular sciences · 2024Article
- Characterization of a novel RNAi yeast insecticide that silences mosquito 5-HT1 receptor genes.Scientific reports · 2023Article
- Mosquito gene targeted RNAi studies for vector control.Functional & integrative genomics · 2023Review
- Effect of marker-free transgenic Chlamydomonas on the control of Aedes mosquito population and on plankton.Parasites & vectors · 2023Article
- Control of Aedes mosquito populations using recombinant microalgae expressing short hairpin RNAs and their effect on plankton.PLoS neglected tropical diseases · 2023Article
- Field trials reveal the complexities of deploying and evaluating the impacts of yeast-baited ovitraps on Aedes mosquito densities in Trinidad, West Indies.Scientific reports · 2022Article
- A Yeast RNA-Interference Pesticide Targeting theInsects · 2021Article
- A Broad-Based Mosquito Yeast Interfering RNA Pesticide TargetingPathogens (Basel, Switzerland) · 2021Article
- Evaluation of large volume yeast interfering RNA lure-and-kill ovitraps for attraction and control of Aedes mosquitoes.Medical and veterinary entomology · 2021Article
- Article
- Advances in oral RNAi for disease vector mosquito research and control.Current opinion in insect science · 2020Review
- Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes.PLoS neglected tropical diseases · 2020Article
- Delivery Methods for RNAi in Mosquito Larvae.Journal of insect science (Online) · 2020Review
- Characterization of an adulticidal and larvicidal interfering RNA pesticide that targets a conserved sequence in mosquito G protein-coupled dopamine 1 receptor genes.Insect biochemistry and molecular biology · 2020Article
- Community acceptance of yeast interfering RNA larvicide technology for control of Aedes mosquitoes in Trinidad.PloS one · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
New mosquito control strategies are vitally needed to address established and emerging arthropod-borne infectious diseases. Here we describe the characterization of a yeast interfering RNA larvicide that was developed through the genetic engineering of Saccharomyces cerevisiae (baker's yeast) to express a short hairpin RNA targeting the Aedes aegypti synaptotagmin (Aae syt) gene. The larvicide effectively silences the Aae syt gene, causes defects at the larval neural synapse, and induces high rates of A. aegypti larval mortality in laboratory, simulated-field, and semi-field trials. Conservation of the interfering RNA target site in multiple mosquito species, but not in humans or other non-target species, suggested that it may function as a broad-range mosquito larvicide. In support of this, consumption of the yeast interfering RNA larvicide was also found to induce high rates of larval mortality in Aedes albopictus, Anopheles gambiae, and Culex quinquefasciatus mosquito larvae. The results of these studies suggest that this biorational yeast interfering RNA larvicide may represent a new intervention that can be used to combat multiple mosquito vectors of human diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.