ArticlePLoS genetics2019
Transcriptomic basis and evolution of the ant nurse-larval social interactome.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Polyphenism Through RNA Chemical Modifications.Molecular ecology · 2026Review
- Social control drove ant evolution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- From Egg to Adult: A Developmental Table of the Ant Monomorium pharaonis.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Evolutionarily stable strategy analysis and its links to demography and genetics through invasion fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Active Inferants: An Active Inference Framework for Ant Colony Behavior.Frontiers in behavioral neuroscience · 2021Article
- The genetic mechanism of selfishness and altruism in parent-offspring coadaptation.Science advances · 2020Article
- From phenotype to genotype: the precursor hypothesis predicts genetic influences that facilitate transitions in social behavior.Current opinion in insect science · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development is often strongly regulated by interactions among close relatives, but the underlying molecular mechanisms are largely unknown. In eusocial insects, interactions between caregiving worker nurses and larvae regulate larval development and resultant adult phenotypes. Here, we begin to characterize the social interactome regulating ant larval development by collecting and sequencing the transcriptomes of interacting nurses and larvae across time. We find that the majority of nurse and larval transcriptomes exhibit parallel expression dynamics across larval development. We leverage this widespread nurse-larva gene co-expression to infer putative social gene regulatory networks acting between nurses and larvae. Genes with the strongest inferred social effects tend to be peripheral elements of within-tissue regulatory networks and are often known to encode secreted proteins. This includes interesting candidates such as the nurse-expressed giant-lens, which may influence larval epidermal growth factor signaling, a pathway known to influence various aspects of insect development. Finally, we find that genes with the strongest signatures of social regulation tend to experience relaxed selective constraint and are evolutionarily young. Overall, our study provides a first glimpse into the molecular and evolutionary features of the social mechanisms that regulate all aspects of social life.
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