Evidence map›Paper›PMID 31107610›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Inhibition of intestinal villus cell Na/K-ATPase mediates altered glucose and NaCl absorption in obesity-associated diabetes and hypertension.

Balasubramanian Palaniappan, Subha Arthur, Vijaya Lakshmi Sundaram, Molly Butts, Shanmuga Sundaram, Kathiresh Mani, Soudamani Singh, Niraj Nepal, Uma Sundaram

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Monosodium glutamate-mediated CaPhysiological reports · 2026
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  7. G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  8. Biomolecules · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Unique Regulation of Intestinal Villus Epithelial ClInternational journal of molecular sciences · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Balasubramanian PalaniappanDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Subha ArthurDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Vijaya Lakshmi SundaramDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Molly ButtsDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Shanmuga SundaramDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Kathiresh ManiDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Soudamani SinghDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Niraj NepalDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Uma SundaramDepartment of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
Marshall University · US

Funding

Regulation of Tight Junction Molecular Composition by Na/K-ATPaseP20GM121299 · NIGMS · MARSHALL UNIVERSITY · PI HAYNES, JENNIFER · 2018 to 2022
$10.6M
REGULATION OF INTESTINAL NA ABSORPTIONR01DK067420 · NIDDK · WEST VIRGINIA UNIVERSITY · PI SUNDARAM, UMA · 2004 to 2016
$3.2M
Regulation of amino acid absorption in the mammalian small intestineR01DK108054 · NIDDK · MARSHALL UNIVERSITY · PI SUNDARAM, UMA · 2016 to 2020
$2.4M
Regulation of intestinal NaCl absorptionI01BX003443 · VA · HUNTINGTON VETERANS AFFAIRS MED CTR · PI Uma Sundaram · 2017 to 2026
–
BLRD VA I01 BX003443NIDDK NIH HHS R01 DK067420NIDDK NIH HHS R01 DK108054NIGMS NIH HHS P20 GM121299
6 · The paper itself

Abstract

During obesity, diabetes and hypertension inevitably coexist and cause innumerable health disparities. In the obesity, diabetes, and hypertension triad (ODHT), deregulation of glucose and NaCl homeostasis, respectively, causes diabetes and hypertension. In the mammalian intestine, glucose is primarily absorbed by Na-glucose cotransport 1 (SGLT1) and coupled NaCl by the dual operation of Na-H exchange 3 (NHE3) and Cl-HCO

Indexed as

AnimalsBlotting, WesternCell LineFluorescent Antibody TechniqueGlucoseHypertensionIntestinal AbsorptionIntestinal MucosaIntestinesMaleMicrovilliObesityRatsRNA InterferenceSodium ChlorideSodium-Potassium-Exchanging ATPaseGlucoseSodium ChlorideSodium-Potassium-Exchanging ATPaseBBMDRANHE3PAT1SGLT1

Identifiers

PMID31107610
PMCPMC6662973
OpenAlexW2946732136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.