Evidence map›Paper›PMID 31107546›Full record

ArticleInternational journal of cancer2020

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition.

Mireia Obón-Santacana, Leila Luján-Barroso, Heinz Freisling, Sabine Naudin, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Vinciane Rebours, Tilman Kühn, Verena Katzke, Heiner Boeing and 29 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 12 countries.

Mireia Obón-SantacanaOncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain.ORCID 0000-0003-4646-3513
Leila Luján-BarrosoBellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Heinz FreislingNutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, Lyon, France.
Sabine NaudinNutritional Methodology and Biostatistics Group, International Agency for Research on Cancer, Lyon, France.
Marie-Christine Boutron-RuaultCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.ORCID 0000-0002-5956-5693
Francesca Romana ManciniCESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.ORCID 0000-0003-2297-3869
Vinciane ReboursPancreatology Department, Beaujon Hospital, DHU Unity, AP-HP, Clichy, and Paris-Diderot University, Paris, France.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Reserach Center (DKFZ), Heidelberg, Germany.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Reserach Center (DKFZ), Heidelberg, Germany.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition (DIfE) Postdam-Rehbrücke, Nuthetal, Germany.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Anja OlsenDanish Cancer Society Research Center, Copenhagen, Denmark.
Kim OvervadSection for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Cristina LasherasDepartment of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.
Miguel Rodríguez-BarrancoConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Pilar AmianoConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Carmen SantiusteConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Eva ArdanazConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Kay-Thee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Nicholas J WarehamMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Julie A SchmidtCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7733-8750
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Paschalis ThriskosHellenic Health Foundation, Athens, Greece.
Eleni PeppaHellenic Health Foundation, Athens, Greece.
Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Sara GrioniEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Rosario TuminoCancer Registry and Histopathology Department, "Civic - M. P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy.
Salvatore PanicoDepartment of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Veronica SciannameoUnit of Epidemiology, Regional Health Service ASL TO3, Turin, Italy.
Roel VermeulenInstitute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.
Emily SonestedtNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Malin SundDepartment of Surgical and Preoperative Sciences, Umeå University, Umeå, Sweden.
Elisabete WeiderpassDepartment of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
Carlos A GonzálezBellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Eric J DuellBellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0001-5256-0163
Institut d'Investigació Biomédica de Bellvitge · ESCentre international de recherche sur le cancer · FRHellenic Health Foundation · GRInserm · FRGerman Cancer Research Center · DEUniversity of Cambridge · GBAarhus University · DKBiogipuzkoa Health Research Institute · ESDanish Cancer Society · DKFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Institute of Human Nutrition · DEImperial College London · GBInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESLund University · SEOslo University Hospital · NOPrevention Institute · USRegional Health · USUiT The Arctic University of Norway · NO

Funding

Cancer Research UK 14136Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_UU_12015/1Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1World Health Organization 001
6 · The paper itself

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Indexed as

DietNutsSeedsCarcinoma, Pancreatic DuctalEuropeFemaleHumansMaleMiddle AgedPancreatic NeoplasmsProportional Hazards ModelsProspective StudiesRisk FactorsSurveys and QuestionnairesdietEPICintakenutspancreatic cancerprospective cohort studyseeds

Identifiers

PMID31107546
PMCPMC7340534
OpenAlexW2945737086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.