Evidence map›Paper›PMID 31107529›Full record

ArticleAmerican journal of epidemiology2019

Methodological Challenges When Studying Distance to Care as an Exposure in Health Research.

Ellen C Caniglia, Rebecca Zash, Sonja A Swanson, Kathleen E Wirth, Modiegi Diseko, Gloria Mayondi, Shahin Lockman, Mompati Mmalane, Joseph Makhema, Scott Dryden-Peterson and 4 more

Abstract read
In one paragraph

Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Does marginalization status and distance from the hospital impact the timing of pediatric pyeloplasty in a universal access-to-care system?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ellen C CanigliaDepartment of Population Health, New York University School of Medicine, New York, New York.
Rebecca ZashDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Sonja A SwansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Kathleen E WirthDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Modiegi DisekoBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Gloria MayondiBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Shahin LockmanBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Mompati MmalaneBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Joseph MakhemaBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Scott Dryden-PetersonBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kalé Z Kponee-Shovein
Oaitse JohnBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Eleanor J MurrayDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Roger L ShapiroDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Funding

PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Botswana Birth Outcomes Surveillance ExtensionR01HD095766 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHAPIRO, ROGER L · 2018 to 2022
$3.3M
Birth Outcomes Surveillance in BotswanaR01HD080471 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHAPIRO, ROGER L · 2014 to 2018
$2.6M
Expansion of research and mentoring to improve birth outcomes and treatment outcomes among HIV-affected children in BotswanaK24AI131924 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Roger L Shapiro · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI131924NIAID NIH HHS T32 AI007433NICHD NIH HHS R01 HD080471NICHD NIH HHS R01 HD095766
6 · The paper itself

Abstract

Distance to care is a common exposure and proposed instrumental variable in health research, but it is vulnerable to violations of fundamental identifiability conditions for causal inference. We used data collected from the Botswana Birth Outcomes Surveillance study between 2014 and 2016 to outline 4 challenges and potential biases when using distance to care as an exposure and as a proposed instrument: selection bias, unmeasured confounding, lack of sufficiently well-defined interventions, and measurement error. We describe how these issues can arise, and we propose sensitivity analyses for estimating the degree of bias.

Indexed as

BiasCausalityConfounding Factors, EpidemiologicGeography, MedicalHealth Services AccessibilityTravelBotswanaFemaleHealth Services ResearchHumansInfant, NewbornPopulation SurveillancePregnancyPregnancy OutcomeSelection BiasStillbirthcausal diagramscausal inferencedistance to careidentifiability conditionsinstrumental variablesselection biasunmeasured confoundingwell-defined interventions

Identifiers

PMID31107529
PMCPMC6735874

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.