ArticleCritical care medicine2019
Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults.
Article in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Objective and subjective cognition in survivors of COVID-19 one year after ICU discharge: the role of demographic, clinical, and emotional factors.Critical care (London, England) · 2023Trial
- Rethinking Mechanical Ventilation: Can Ventilation Mode Influence Long-Term Cognitive Outcomes in ICU Patients with COVID-19?Journal of clinical medicine · 2026Article
- Assessing Risk Factors for Cognitive Decline Using Electronic Health Record Data: A Scoping Review.Research square · 2024Article
- Instruments Assessing Cognitive Impairment in Survivors of Critical Illness and Reporting of Race Norms: A Systematic Review.Critical care explorations · 2022Review
- Comorbidity-adjusted NEWS predicts mortality in suspected patients with COVID-19 from nursing homes: Multicentre retrospective cohort study.Journal of advanced nursing · 2022Article
- Novel Prehospital Phenotypes and Outcomes in Adult-Patients with Acute Disease.Journal of medical systems · 2022Article
- Identifying cues of distorted memories in intensive care by focus group interview of nurses.Nursing open · 2022Article
- Virtual Reality-Based Early Neurocognitive Stimulation in Critically Ill Patients: A Pilot Randomized Clinical Trial.Journal of personalized medicine · 2021Article
- Brain MRI after critical care admission: A longitudinal imaging study.Journal of critical care · 2021Article
- Association of Hospitalization with Long-Term Cognitive Trajectories in Older Adults.Journal of the American Geriatrics Society · 2021Observational
- Daytime-to-Nighttime Sleep Ratios and Cognitive Impairment in Older Intensive Care Unit Survivors.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2021Article
- Family automated voice reorientation (FAVoR) intervention for mechanically ventilated patients in the intensive care unit: Study protocol for a randomized controlled trial.Contemporary clinical trials · 2021Article
- Cut-Off Values of the Post-Intensive Care Syndrome Questionnaire for the Screening of Unplanned Hospital Readmission within One Year.Journal of Korean Academy of Nursing · 2020Article
- Executive Function, Dexterity, and Discharge Disposition in Older Intensive Care Unit Survivors.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2020Article
- Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study.Critical care (London, England) · 2020Observational
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13 authors.
Funding
Abstract
objectivesPatients requiring admission to an ICU may subsequently experience cognitive decline. Our objective was to investigate longitudinal cognitive trajectories in older adults hospitalized in ICUs. We hypothesized that individuals hospitalized for critical illness develop greater cognitive decline compared with those who do not require ICU admission.
designA retrospective cohort study using prospectively collected cognitive scores of participants enrolled in the Mayo Clinic Study of Aging and ICU admissions retrospectively ascertained from electronic medical records. A covariate-adjusted linear mixed effects model with random intercepts and slopes assessed the relationship between ICU admissions and the slope of global cognitive z scores and domains scores (memory, attention/executive, visuospatial, and language).
settingICU admissions and cognitive scores in the Mayo Clinic Study of Aging from October 1, 2004, to September 11, 2017. PATIENTS: Nondemented participants age 50 through 91 at enrollment in the Mayo Clinic Study of Aging with an initial cognitive assessment and at least one follow-up visit.
interventionsNone. MEASUREMENTS AND MAIN
resultsOf 3,673 participants, 372 had at least one ICU admission with median (25-75th percentile) follow-up after first ICU admission of 2.5 years (1.2-4.4 yr). For global cognitive z score, admission to an ICU was associated with greater decline in scores over time compared with participants not requiring ICU admission (difference in annual slope = -0.028; 95% CI, -0.044 to -0.012; p < 0.001). ICU admission was associated with greater declines in memory (-0.029; 95% CI, -0.047 to -0.011; p = 0.002), attention/executive (-0.020; 95% CI, -0.037 to -0.004; p = 0.016), and visuospatial (-0.013; 95% CI, -0.026 to -0.001; p = 0.041) domains. ICU admissions with delirium were associated with greater declines in memory (interaction p = 0.006) and language (interaction p = 0.002) domains than ICU admissions without delirium.
conclusionsIn older adults, ICU admission was associated with greater long-term cognitive decline compared with patients without ICU admission. These findings were more pronounced in those who develop delirium while in the ICU.
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