Evidence map›Paper›PMID 31107246›Full record

ReviewThe Journal of clinical investigation2019

The role of macrophages in the resolution of inflammation.

Satoshi Watanabe, Michael Alexander, Alexander V Misharin, G R Scott Budinger

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 567 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
567citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

567 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026
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507 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Satoshi WatanabeDivision of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Michael AlexanderDivision of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALAN R HAUSER · 2018 to 2026
$24.7M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
Signaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3M
Differential role of tissue-resident and monocyte-derived alveolar macrophages in the development of pulmonary fibrosisR56HL135124 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MISHARIN, ALEXANDER · 2017 to 2017
$460k
The Role of Mitochondrial Reactive Oxygen Species in TGF-Beta SignalingI01BX000201 · VA · JESSE BROWN VA MEDICAL CENTER · PI BUDINGER, GR SCOTT, JAIN, MANU · 2011 to 2017
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Mitochondrial metabolism as a therapeutic target in pulmonary fibrosisI01CX001777 · VA · JESSE BROWN VA MEDICAL CENTER · PI GR Scott Budinger, MANU JAIN · 2019 to 2026
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BLRD VA I01 BX000201CSRD VA I01 CX001777NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R56 HL135124NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIA NIH HHS P01 AG049665NIEHS NIH HHS R01 ES013995
6 · The paper itself

Abstract

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.

Indexed as

Immunity, InnateAnimalsHomeostasisHumansInflammationMacrophagesRegeneration

Identifiers

PMID31107246
PMCPMC6597225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.