Evidence map›Paper›PMID 31107113›Full record

ArticleBiopreservation and biobanking2019

Monitoring Dehydration and Clearing in Tissue Processing for High-Quality Clinical Pathology.

Melissa L Lerch, Daniel R Bauer, Abbey Theiss, David Chafin, Michael Otter, Geoffrey S Baird

Open access · hybridAbstract read
In one paragraph

Article in Biopreservation and biobanking, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa L Lerch1Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington.
Daniel R Bauer2Ventana Medical Systems, Inc., Tucson, Arizona.
Abbey Theiss2Ventana Medical Systems, Inc., Tucson, Arizona.
David Chafin2Ventana Medical Systems, Inc., Tucson, Arizona.
Michael Otter2Ventana Medical Systems, Inc., Tucson, Arizona.
Geoffrey S Baird1Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington.
Ventana Research Corporation (United States) · USUniversity of Washington Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of precision testing for disease diagnosis has advanced medicine by specifically matching patients with drugs to treat specific diseases. High-quality diagnostics start with high-quality tissue specimens. The development and optimization of tissue handling and processing have lagged behind bioassay development. Ultrasound time-of-flight (TOF) technology has been successfully used to monitor the critical processing step of tissue fixation with formalin. In this study, we expand the use of this technology to monitor tissue dehydration and clearing by analyzing TOF signals from 270 different specimens, representing 13 different tissue types obtained through surgical resections. We determined the time constant τ

Indexed as

DehydrationHistocytological Preparation TechniquesHumansImmunohistochemistryPathology, ClinicalTissue Fixationclearingdehydrationimmunohistochemistrypreanalyticsquality assurancetissue processing

Identifiers

PMID31107113
PMCPMC6703239
OpenAlexW2946754347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.