Evidence map›Paper›PMID 31106498›Full record

ArticleJournal of clinical laboratory analysis2019

Serum galectin-3 concentrations in patients with ankylosing spondylitis.

Ming-Yu Cao, Jiang Wang, Xiao-Liang Gao, Ya-Bin Hu

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Diagnostic Power of Galectin-3 in Rheumatic Diseases.Journal of clinical medicine · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ming-Yu CaoDepartment of Joint Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Jiang WangDepartment of Traumatic Orthopaedics, Sixth Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Xiao-Liang GaoDepartment of Spine Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Ya-Bin HuDepartment of Spine Surgery, The Second Hospital of Nanjing, Nanjing, China.ORCID https://orcid.org/0000-0002-2940-2711
Xinjiang Medical University · CNNanjing Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of our study was to assess potential correlations between serum galectin-3 concentrations and Ankylosing Spondylitis Disease Activity (ASDAS) index in patients with ankylosing spondylitis (AS).

methodsA total of 112 patients with AS were included, and 130 healthy subjects were considered as controls. We collected the detailed medical history, and ASDAS index was used to assess the disease severity in patients with AS.

resultsThe serum galectin concentrations were higher in AS patients compared to the health groups (14.1 ± 9.6 vs 9.2 ± 3.7, P < 0.001). The correlation analysis showed that serum galectin concentrations were significantly positively correlated with C-reactive protein and erythrocyte sedimentation rate (r = 0.369, P < 0.001; r = 0.240, P = 0.011). In addition, the positively correlation of serum galectin-3 with global pain index (r = 0.238, P = 0.011) was observed in AS patients. A significant positively correlation between serum galectin and ASDAS index in AS patients was found (r = 0.367; P < 0.001). In multiple linear regression analysis, the results indicated that increased serum galectin still was correlated with ASDAS index (r = 0.322, P < 0.001) in patients with AS.

conclusionsSerum galectin concentrations were found to be correlated with ASDAS index in patients with AS.

Indexed as

AdultBiomarkersBlood ProteinsBlood SedimentationCase-Control StudiesC-Reactive ProteinFemaleGalectin 3GalectinsHumansLinear ModelsMaleSpondylitis, AnkylosingBiomarkersBlood ProteinsC-Reactive ProteinGalectin 3GalectinsLGALS3 protein, humanankylosing spondylitisASDAS indexserum galectin-3

Identifiers

PMID31106498
PMCPMC6642303
OpenAlexW2946100821

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.