Evidence map›Paper›PMID 31106427›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2019

Anxiety in the family: a genetically informed analysis of transactional associations between mother, father and child anxiety symptoms.

Yasmin I Ahmadzadeh, Thalia C Eley, Leslie D Leve, Daniel S Shaw, Misaki N Natsuaki, David Reiss, Jenae M Neiderhiser, Tom A McAdams

Open access · hybridAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Yasmin I AhmadzadehSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-1333-1661
Thalia C EleySocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-6458-0700
Leslie D LeveCollege of Education, University of Oregon, Eugene, OR, USA.ORCID 0000-0003-3061-4524
Daniel S ShawDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Misaki N NatsuakiDepartment of Psychology, University of California, Riverside, Riverside, CA, USA.
David ReissChild Study Center, Yale University, New Haven, CT, USA.
Jenae M NeiderhiserDepartment of Psychology, Pennsylvania State University, State College, PA, USA.
Tom A McAdamsSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-6825-3499
King's College London · GBPennsylvania State University · USUniversity of California, Riverside · USUniversity of Oregon · USUniversity of Pittsburgh · USYale University · US

Funding

The Early Growth and Development Study Pediatric CohortUH3OD023389 · OD · UNIVERSITY OF OREGON · PI Jody M. Ganiban, Leslie Diane Leve · 2018 to 2026
$16.6M
The Early Growth and Development Study: Family Process, Genes and School EntryR01HD042608 · NICHD · OREGON SOCIAL LEARNING CENTER, INC. · PI CAPALDI, DEBORAH M. · 2002 to 2011
$14.9M
The Early Growth and Development Study Pediatric CohortUG3OD023389 · OD · UNIVERSITY OF OREGON · PI GANIBAN, JODY M., LEVE, LESLIE DIANE · 2016 to 2024
$7.5M
Gene-Environment Interplay and Development of Psychiatric Symptoms in ChildrenR01MH092118 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LEVE, LESLIE DIANE, NEIDERHISER, JENAE M. · 2010 to 2014
$3.1M
Family and Peer Processes and G-E Interplay in Middle School: An Adoption StudyR56HD042608 · NICHD · UNIVERSITY OF OREGON · PI LEVE, LESLIE DIANE · 2014 to 2015
$700k
Medical Research Council G0500079Medical Research Council MR/M021475/1NICHD NIH HHS R01 HD042608NICHD NIH HHS R56 HD042608NIH HHS UG3 OD023389NIH HHS UH3 OD023389NIMH NIH HHS R01 MH092118ODCDC CDC HHS UH3-OD023389Royal Society 107706/Z/15/ZWellcome Trust 107706
6 · The paper itself

Abstract

backgroundAnxiety in parents is associated with anxiety in offspring, although little is known about the mechanisms underpinning these intergenerational associations. We conducted the first genetically sensitive study to simultaneously examine the effects of mother, father and child anxiety symptoms on each other over time.

methodAdoptive parent and child symptoms were measured at child ages 6, 7 and 8 years from 305 families involved in the Early Growth and Development Study, using a prospective adoption design. Children were adopted at birth to nonrelatives, and composite data on internalising problems within birth families were used as a proxy measure of offspring inherited risk for anxiety. Structural equation models were fitted to the data to examine prospective associations between adoptive mother, father and child symptoms, whilst accounting for individuals' symptom stability over time.

resultsChild anxiety symptoms at age 7 predicted adoptive mothers' anxiety symptoms at age 8. No mother-to-child or child-to-father effects were observed. These results were consistent in sensitivity analyses using only paternal offspring reports and using a second measure of child anxiety symptoms. Fathers' anxiety symptoms at child age 6 prospectively predicted child symptoms, but only when paternal offspring reports were included in the model. Composite data on birth family internalising problems were not associated with child anxiety symptoms.

conclusionsResults show environmentally mediated associations between parent and child anxiety symptoms. Results support developmental theories suggesting that child anxiety symptoms can exert influence on caregivers, and mothers and fathers may play unique roles during the development of child symptoms. Further research is needed on the role of genetic transmission associated with anxiety symptoms in biologically related families. In the meantime, researchers and clinicians should strive to include fathers in assessments and consider the effects of child symptoms on caregivers.

Indexed as

Child, AdoptedChild of Impaired ParentsFathersMothersParent-Child RelationsSocial EnvironmentAdultAnxietyChildFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansLongitudinal StudiesMaleAnxietygeneticslongitudinalparent-child relationshipsstructural equation modelling

Identifiers

PMID31106427
PMCPMC6856374
OpenAlexW2945753248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.