Evidence map›Paper›PMID 31106289›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2018

Obesity in relation to serum persistent organic pollutant concentrations in CHAMACOS women.

Marcella Warner, Stephen Rauch, Eric S Coker, Kim Harley, Katherine Kogut, Andreas Sjödin, Brenda Eskenazi

Open access · goldAbstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
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  6. Additive partially linear model for pooled biomonitoring data.Computational statistics & data analysis · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marcella WarnerCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
Stephen RauchCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
Eric S CokerCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
Kim HarleyCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
Katherine KogutCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
Andreas SjödinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, California, USA.
University of California, Berkeley · USCenter for Environmental Health · USCenters for Disease Control and Prevention · US

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
New Mexico NIEHS CenterP30ES012072 · NIEHS · UNIVERSITY OF NEW MEXICO · PI BURCHIEL, SCOTT WILLIAM · 2003 to 2007
$4.1M
IRS insecticides for malaria control and child neurodevelopment in South AfricaR01ES020360 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2011 to 2015
$3.7M
DDT & PBDE exposure, puberty onset and neurodevelopment in Mexican-American girlsR01ES017054 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2009 to 2013
$3.2M
Navajo Uranium Assessment and Kidney Health ProjectR01ES014565 · NIEHS · UNIVERSITY OF NEW MEXICO · PI LEWIS, JOHNNYE L · 2006 to 2010
$2.4M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
NIEHS NIH HHS P01 ES009605NIEHS NIH HHS P30 ES012072NIEHS NIH HHS R01 ES014565NIEHS NIH HHS R01 ES017054NIEHS NIH HHS R01 ES020360NIEHS NIH HHS R24 ES028529
6 · The paper itself

Abstract

backgroundEnvironmental exposure to endocrine-disrupting chemicals (EDCs), including persistent organic pollutants (POPs), has been hypothesized to increase risk of obesity. Using data from the Center for Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, we examined the longitudinal relationship between serum concentrations of a POPs mixture and several obesity measures.

methodsConcentrations of 17 POPs were measured in serum collected in 2009-2011 from 468 CHAMACOS women. Anthropometry measurements and personal interviews were completed at up to three study visits between 2009 and 2014. We assessed the relationship of serum POPs concentrations with adiposity measures longitudinally using generalized estimating equation (GEE) models. We implemented Bayesian Kernel Machine Regression (BKMR) to elucidate the effects of joint exposure to the POPs mixture.

resultsIn GEE models, positive associations with BMI were found for dichlorodiphenyltrichloroethane (Q4 vs Q1: adjusted-β = 3.2 kg/m

conclusionIn summary, we found significant associations of serum POPs with several adiposity measures using both conventional regressions and BKMR. Our results provide support for the chemical obesogen hypothesis, that exposure to EDCs may alter risk for later obesity.

Identifiers

PMID31106289
PMCPMC6521959
OpenAlexW2901849439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.