Evidence map›Paper›PMID 31106288›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2018

Maternal peripartum urinary pyrethroid metabolites are associated with thinner children at 3.5 years in the VHEMBE birth cohort (Limpopo, South Africa).

Jonathan Y Huang, Brenda Eskenazi, Riana Bornman, Stephen Rauch, Jonathan Chevrier

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pyrethroid pesticide exposure and placental effects.Molecular and cellular endocrinology · 2023
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Jonathan Y HuangDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, California.
Riana BornmanInstitute for Sustainable Malaria Control, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.
Stephen RauchCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, California.
Jonathan ChevrierDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
Center for Environmental Health · USMcGill University · CAUniversity of Pretoria · ZA

Funding

IRS insecticides for malaria control and child neurodevelopment in South AfricaR01ES020360 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2011 to 2015
$3.7M
NIEHS NIH HHS R01 ES020360
6 · The paper itself

Abstract

backgroundPyrethroids are the most widely used insecticides globally for domestic, agricultural, and malaria vector control. In 10 countries, dichlorodiphenyl trichloroethane (DDT) is also used for the latter. Thus, high exposure to pyrethroids and DDT have been reported among women and children from rural and/or malaria-endemic areas. Experimental studies suggest that fetal exposure to pyrethroids, particularly cypermethrin, and DDT may have sex-specific growth effects. However, epidemiologic investigations are scarce and inconsistent and have not considered postnatal environment or susceptibility factors.

methodsIn 665 mother-child dyads participating in the Venda Health Examination of Mothers, Babies, and their Environment (VHEMBE), a rural South African birth cohort with high insecticide exposure, we examined associations of maternal peripartum uri-nary pyrethroid metabolites and serum DDT concentrations with child anthropometrics at 3.5 years using multivariable linear regression. We investigated effect modification by child sex, maternal nutrition and HIV status, and household poverty.

resultsPyrethroid metabolites DISCUSSION: In a population with ubiquitous pyrethroid exposure, maternal concentrations of metabolites of cypermethrin and permethrin were associated with thinness at 3.5 years.

Indexed as

Child growthCypermethrinDDT/EPyrethroid

Identifiers

PMID31106288
PMCPMC6516496
OpenAlexW4248716222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.