ArticleScience advances2019
Dental evolutionary rates and its implications for the Neanderthal-modern human divergence.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Inferring hominin history with recurrent gene flow from single unphased genomes and a two-locus statistic.bioRxiv : the preprint server for biology · 2026Article
- Article
- Neandertal Cold Adaptation: Technological, Anatomical, and Physiological Responses to Cold Stress in One of Our Closest Fossil Relatives.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The emergence of genetic variants linked to brain and cognitive traits in human evolution.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.Cell genomics · 2025Article
- Semicircular canals shed light on bottleneck events in the evolution of the Neanderthal clade.Nature communications · 2025Article
- A Macaque Model for the Effects of Hybridization on Body Size.American journal of biological anthropology · 2025Article
- Evolution is in the details: Regulatory differences in modern human and Neanderthal.Computational and structural biotechnology journal · 2025Article
- Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation.Science (New York, N.Y.) · 2024Article
- Evolutionary and functional analyses of LRP5 in archaic and extant modern humans.Human genomics · 2024Article
- Dating ancient splits in phylogenetic trees, with application to the human-Neanderthal split.BMC genomic data · 2024Article
- Archaic Introgression Shaped Human Circadian Traits.Genome biology and evolution · 2023Article
- Rules of teeth development align microevolution with macroevolution in extant and extinct primates.Nature ecology & evolution · 2023Article
- A Customized Human Mitochondrial DNA Database (hMITO DB v1.0) for Rapid Sequence Analysis, Haplotyping and Geo-Mapping.International journal of molecular sciences · 2023Article
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- The relevance of the unique anatomy of the human prefrontal operculum to the emergence of speech.Communications biology · 2023Article
- Evolution of Homo in the Middle and Late Pleistocene.Journal of human evolution · 2022Review
- Temporal mapping of derived high-frequency gene variants supports the mosaic nature of the evolution of Homo sapiens.Scientific reports · 2022Article
- Resolving the "muddle in the middle": The case for Homo bodoensis sp. nov.Evolutionary anthropology · 2022Article
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Abstract
The origin of Neanderthal and modern human lineages is a matter of intense debate. DNA analyses have generally indicated that both lineages diverged during the middle period of the Middle Pleistocene, an inferred time that has strongly influenced interpretations of the hominin fossil record. This divergence time, however, is not compatible with the anatomical and genetic Neanderthal affinities observed in Middle Pleistocene hominins from Sima de los Huesos (Spain), which are dated to 430 thousand years (ka) ago. Drawing on quantitative analyses of dental evolutionary rates and Bayesian analyses of hominin phylogenetic relationships, I show that any divergence time between Neanderthals and modern humans younger than 800 ka ago would have entailed unexpectedly rapid dental evolution in early Neanderthals from Sima de los Huesos. These results support a pre-800 ka last common ancestor for Neanderthals and modern humans unless hitherto unexplained mechanisms sped up dental evolution in early Neanderthals.
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