Evidence map›Paper›PMID 31106153›Full record

ArticleFrontiers in oncology2019

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and

Noura Al-Zeheimi, Adviti Naik, Charles Saki Bakheit, Marwa Al Riyami, Adil Al Ajarrah, Suaad Al Badi, Khalid Al Baimani, Kamran Malik, Zamzam Al Habsi, Mansour S Al Moundhri and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Preclinical evaluation ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Neuropilin (NRPs) Related Pathological Conditions and Their Modulators.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Noura Al-ZeheimiDepartment of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.
Adviti NaikQatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar.
Charles Saki BakheitDepartment of Mathematics and Statistics, Sultan Qaboos University, Muscat, Oman.
Marwa Al RiyamiDepartment of Pathology, College of Medicine, Sultan Qaboos University, Muscat, Oman.
Adil Al AjarrahDepartment of Surgery, Sultan Qaboos University Hospital, Muscat, Oman.
Suaad Al BadiDepartment of Pathology, College of Medicine, Sultan Qaboos University, Muscat, Oman.
Khalid Al BaimaniMedical Oncology Unit, Department of Medicine, College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
Kamran MalikDepartment of Surgery, Wrexham Maelor Hospital, Wrexham, United Kingdom.
Zamzam Al HabsiDepartment of Surgery, Sultan Qaboos University Hospital, Muscat, Oman.
Mansour S Al MoundhriMedical Oncology Unit, Department of Medicine, College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
Sirin A AdhamDepartment of Biology, College of Science, Sultan Qaboos University, Muscat, Oman.
Sultan Qaboos University · OMSultan Qaboos University Hospital · OMHamad bin Khalifa University · QAWrexham Maelor Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating proteins hold a potential benefit as biomarkers for precision medicine. Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. To further identify the role of NRP-1 and its interacting molecules in correspondence with patients' response to neoadjuvant chemotherapy (NAC), we conducted a comparative study on blood and tissue samples collected from a cohort of locally advanced breast cancer patients, before and after neoadjuvant chemotherapy (NAC). From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor

Indexed as

biomarkerbloodbreastneoadjuvantneuropilin-1PlGFresponseSNAI1

Identifiers

PMID31106153
PMCPMC6494932
OpenAlexW2942194709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.