Evidence map›Paper›PMID 31106001›Full record

ArticleAmerican journal of cancer research2019

Epitranscriptomic m6A modification in the stem cell field and its effects on cell death and survival.

Jiaxin Chen, Chan Wang, Weiqiang Fei, Xiao Fang, Xiaotong Hu

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 39 citations in OpenAlex.

  1. RNA mJournal of advanced research · 2026
    Article
  2. Review
  3. mCells · 2025
    Review
  4. The Role of M6A LncRNA Modification in Papillary Thyroid Cancer.International journal of molecular sciences · 2025
    Review
  5. Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025
    Review
  6. Article
  7. Progression of mCell death discovery · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Crosstalk among mJournal of hematology & oncology · 2022
    Review
  14. The mAnnals of translational medicine · 2022
    Article
  15. mAutophagy · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. NOxidative medicine and cellular longevity · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiaxin ChenBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 310016, Zhejiang, China.
Chan WangBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 310016, Zhejiang, China.
Weiqiang FeiBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 310016, Zhejiang, China.
Xiao FangBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 310016, Zhejiang, China.
Xiaotong HuBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University Hangzhou 310016, Zhejiang, China.
Sir Run Run Shaw Hospital · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reversible N6-methyl-adenosine (m6A) modification of messenger RNAs (mRNAs) has generated much interest in the field of stem cell modulation in recent years. Meanwhile, mounting evidence has shown that many physiopathological processes concerning cell death and survival harbor this chemical mark. Our review provides an overview of the m6A epitranscriptomic field and the updated mechanisms of m6A decoration in stem cell regulation. Furthermore, we focus on the role of m6A in DNA damage and the immune response, cell apoptosis, autophagy, and senescence, followed by recent advancements in m6A-induced viral replication. The function of abundant RNA-binding proteins (RBPs) identified in m6A regulatory systems will also be discussed in this review, highlighting their far-reaching implications in cellular m6A machinery and disease treatment.

Indexed as

apoptosis and autophagyDNA damage responseimmune responsem6ARNA-binding proteinsstem cellviral replication

Identifiers

PMID31106001
PMCPMC6511641
OpenAlexW2998676979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.