ReviewAmerican journal of cancer research2019
A comprehensive review of Hep-2 cell line in translational research for laryngeal cancer.
Review in American journal of cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Programmed cell death in human respiratory syncytial virus infection.Frontiers in cellular and infection microbiology · 2025Pooled it
- A Biomedical Researcher's Guide for Analyzing Short Tandem Repeat (STR) Genotypes of Human Cell Lines and in Vitro Tissue Samples Using Three Standard Authentication Algorithms.Current protocols · 2026Article
- Osage Orange (Pathogens (Basel, Switzerland) · 2025Article
- Insights into the Two Most Common Cancers of Primitive Gut-Derived Structures and Their Microbial Connections.Medicina (Kaunas, Lithuania) · 2024Review
- Detailed analysis of low temperature inactivation of respiratory syncytial virus.Scientific reports · 2024Article
- Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.JCI insight · 2024Article
- Nanoparticles with a Lipid Core Can Enhance the Infection of Epithelial Cells with an Enterovirus.Intervirology · 2024Article
- The mechanisms of action of metformin on head and neck cancer in the pre-clinical setting: a scoping review.Frontiers in oncology · 2024Article
- In Vitro Models of Head and Neck Cancer: From Primitive to Most Advanced.Journal of personalized medicine · 2023Review
- Investigation of Cytotoxic and Apoptotic Effects of Styrax Liquidus Obtained From Liquidambar orientalis Miller (Hamamelidaceae) on HEp-2 Cancer Cell with Caspase Pathway.The Eurasian journal of medicine · 2023Article
- Herb Robert's Gift against Human Diseases: Anticancer and Antimicrobial Activity ofPharmaceutics · 2023Article
- Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.bioRxiv : the preprint server for biology · 2023Article
- Diagnostic and Prognostic Value of microRNAs in Patients with Laryngeal Cancer: A Systematic Review.Non-coding RNA · 2023Review
- Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn.Frontiers in cell and developmental biology · 2023Article
- The group AInfectious microbes & diseases · 2022Article
- Cell line authentication: a necessity for reproducible biomedical research.The EMBO journal · 2022Article
- Evolution of proteomics technologies for understanding respiratory syncytial virus pathogenesis.Expert review of proteomics · 2021Article
- Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Characterization of a new case of XMLV (Bxv1) contamination in the human cell line Hep2 (clone 2B).Scientific reports · 2020Article
- Lineage, Antimicrobial Resistance and Virulence of Citrobacter spp.Pathogens (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell lines represent an invaluable resource in modern science including basic and translational cancer research. Although there have been warnings over the past half century, the number of publications in the literature that erroneously used "non-existent" cell lines is still growing. For example, the Hep-2 cell line, first described in 1954 as laryngeal cancer cells, was reported as soon as in 1966 to be comprised of cervical adenocarcinoma cells derived via HeLa cell line contamination. Notably, the International Cell Line Authentication Committee (ICLAC) reported Hep-2 to be one among 488 misidentified cell lines, and one of 451 cell lines where no authentic stock is known. However, the number of laryngeal cancer research publications using the Hep-2 cell line has greatly increased over the past three decades. A comprehensive review of Hep-2 cell line misuse has been performed to identify the extent of the problem. 1,036 publications referenced in the MEDLINE database from 1954 to the first of January 2018 referred to the purported laryngeal origin of the Hep-2 cell line, with an increasing trend and with a peak of 93 publications in 2014. The rate of publications that focused on laryngeal cancer topics have increased over the past three decades to reach 80% in 2017. This increase was mainly driven by the remarkable productivity of Chinese researchers, of which English-language publications represented 76% of these articles in 2017. International collaborations and up-to-date national guidelines are needed.
Indexed as
Identifiers
31105993PMC6511639What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.