Tissue window, not the time window, will guide acute stroke treatment.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Accuracy of time to treatment estimates in the CRASH-3 clinical trial: impact on the trial results.Trials · 2020
   Trial
2. Impact of time from symptom onset to recanalization in acute anterior circulation large vessel occlusive stroke with same tissue window: A patient-level pooled analysis of the three randomized controlled trials.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
   Observational
3. Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations.Aging and disease · 2025
   Review
4. Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke.Aging and disease · 2024
   Article
5. Endovascular treatment for basilar artery occlusion: whether the "weekend effect" affects time metrics and clinical outcomes at a comprehensive stroke center.Frontiers in neurology · 2024
   Article
6. The role of automated computed topography perfusion in prediction of hemorrhagic transformation after acute ischemic stroke.The neuroradiology journal · 2023
   Article
7. Endovascular Intervention in Acute Ischemic Stroke: History and Evolution.Biomedicines · 2022
   Review
8. Comparative Assessment of the Proteolytic Stability and Impact of Poly-Arginine Peptides R18 and R18D on Infarct Growth and Penumbral Tissue Preservation Following Middle Cerebral Artery Occlusion in the Sprague Dawley Rat.Neurochemical research · 2021
   Article
9. Systematic review protocol to assess artificial intelligence diagnostic accuracy performance in detecting acute ischaemic stroke and large-vessel occlusions on CT and MR medical imaging.BMJ open · 2021
   Article
10. Silver Jubilee of Stroke Thrombolysis With Alteplase: Evolution of the Therapeutic Window.Frontiers in neurology · 2021
    Review
11. Localized prediction of tissue outcome in acute ischemic stroke patients using diffusion- and perfusion-weighted MRI datasets.PloS one · 2020
    Article

Corrections and comments

• Comment on
  Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset.2019
• Comment on
  Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective.2019

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as