Evidence map›Paper›PMID 31105934›Full record

ReviewF1000Research2019

Recent Advances in Preventing and Managing Postoperative Delirium.

Phillip Vlisides, Michael Avidan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Effect of Dexmedetomidine Dose on Reducing Delirium in Adults: An Indirect Comparison of Controlled Trials.Medical science monitor : international medical journal of experimental and clinical research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Phillip VlisidesDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Michael AvidanDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0001-6248-044X
University of Michigan · USWashington University in St. Louis · US

Funding

Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
ELECTROENCEPHALOGRAPH GUIDANCE OF ANESTHESIA TO ALLEVIATE GERIATRIC SYNDROMES (ENGAGES)UH3AG050312 · NIA · WASHINGTON UNIVERSITY · PI AVIDAN, MICHAEL SIMON · 2015 to 2018
$2.4M
Neurocognitive Recovery following Surgery and General AnesthesiaK23GM126317 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VLISIDES, PHILLIP ELEAS · 2018 to 2021
$764k
NIA NIH HHS R24 AG054259NIA NIH HHS UH3 AG050312NIGMS NIH HHS K23 GM126317
6 · The paper itself

Abstract

Postoperative delirium is a common and harrowing complication in older surgical patients. Those with cognitive impairment or dementia are at especially high risk for developing postoperative delirium; ominously, it is hypothesized that delirium can accelerate cognitive decline and the onset of dementia, or worsen the severity of dementia. Awareness of delirium has grown in recent years as various medical societies have launched initiatives to prevent postoperative delirium and alleviate its impact. Unfortunately, delirium pathophysiology is not well understood and this likely contributes to the current state of low-quality evidence that informs perioperative guidelines. Along these lines, recent prevention trials involving ketamine and dexmedetomidine have demonstrated inconsistent findings. Non-pharmacologic multicomponent initiatives, such as the Hospital Elder Life Program, have consistently reduced delirium incidence and burden across various hospital settings. However, a substantial portion of delirium occurrences are still not prevented, and effective prevention and management strategies are needed to complement such multicomponent non-pharmacologic therapies. In this narrative review, we examine the current understanding of delirium neurobiology and summarize the present state of prevention and management efforts.

Indexed as

DeliriumPostoperative ComplicationsAgedHumansIncidenceAnesthesiaCognitive DysfunctionCognitive ReserveDeliriumNeurocognitiveNeurophysiologyPostoperativeSurgery

Identifiers

PMID31105934
PMCPMC6498743
OpenAlexW2943517730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.