ArticleAmerican journal of translational research2019
Biological characteristics of heat shock protein 90 in human liver cancer cells.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma.Molecular biotechnology · 2025Review
- Advances in the structures, mechanisms and targeting of molecular chaperones.Signal transduction and targeted therapy · 2025Review
- Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888.Medical oncology (Northwood, London, England) · 2023Article
- Comparative RNA-Sequencing Analysis Reveals High Complexity and Heterogeneity of Transcriptomic and Immune Profiles in Hepatocellular Carcinoma Tumors of Viral (HBV, HCV) and Non-Viral Etiology.Medicina (Kaunas, Lithuania) · 2022Article
- The Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma.Cancers · 2021Review
- Anti-Cancer Effects of 3, 3'-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic CaFrontiers in pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary hepatic cancer refers to a malignant tumor that enables lethal cancero-metastasis. And hepatocellular carcinoma (HCC) is a most common cancer, accounting for around 75% of all cases. However, effective screening and diagnostic methods of HCC are limited currently. Heat shock protein 90 (HSP90), a sensitive biomarker, is found marked elevation in various malignancies. Thus, potential association between HSP90 expression and pathological onset of HCC is needed to be investigated. In current human study, plasma samples of advanced HCC patients were collected for biochemical assays, and cancer, non-cancer tissues from biopsy were stained immunohistochemically. In cell culture study, a human HepG2 cell line was subjected to a group of assays followed by HSP90 and inhibitor treatments. As results, the clinical data of HCC patients resulted in abnormal altered levels of serous molecules when compared to diagnostical references. However, these enzymatic changes showed no statistical significance. Significantly, plasma contents of HSP90 in HCC patients were elevated in comparison with those in HCC-free adults (
Indexed as
Identifiers
31105855PMC6511753W2983308626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.