ArticleAmerican journal of translational research2019
Novel methylation-driven genes identified as prognostic indicators for lung squamous cell carcinoma.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- DNA methylation changes in thyroid cancer patients infected with SARS-CoV-2.Updates in surgery · 2026Article
- Diagnostic potential of the B9D2 gene in colorectal cancer based on whole blood gene expression data and machine learning.Discover oncology · 2025Article
- GPR75: Advances, Challenges in Deorphanization, and Potential as a Novel Drug Target for Disease Treatment.International journal of molecular sciences · 2025Review
- Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma.Journal of advanced research · 2023Article
- Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension.Vascular pharmacology · 2023Article
- A new immune signature for survival prediction and immune checkpoint molecules in non-small cell lung cancer.Frontiers in oncology · 2023Article
- Identification ofInternational journal of molecular sciences · 2022Article
- Identification of a glycolysis-related gene signature associated with clinical outcome for patients with lung squamous cell carcinoma.Cancer medicine · 2021Article
- Aberrantly DNA Methylated-Differentially Expressed Genes in Pancreatic Cancer Through an Integrated Bioinformatics Approach.Frontiers in genetics · 2021Article
- Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes.Cell death & disease · 2020Article
- CpG methylation signature defines human temporal lobe epilepsy and predicts drug-resistant.CNS neuroscience & therapeutics · 2020Article
- Methylation-driven genes and their prognostic value in cervical squamous cell carcinoma.Annals of translational medicine · 2020Article
- A prognostic 11-DNA methylation signature for lung squamous cell carcinoma.Journal of thoracic disease · 2020Article
- The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation.Annals of translational medicine · 2020Article
- Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization.Epigenetics & chromatin · 2019Article
- Current Landscape of Epigenetics in Lung Cancer: Focus on the Mechanism and Application.Journal of oncology · 2019Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Lung cancer remains the leading cause of cancer death. DNA methylation plays an essential role in carcinogenesis through regulating gene expression and gene alternative splicing. However, the role of methylation in the tumorigenesis of lung squamous cell carcinoma (SCC) and its association with prognosis remains unclear. Here, we used an integrative approach to evaluate the prognostic value of epigenetic processes in lung SCC by examining the data provided by The Cancer Genome Atlas (TCGA). We found that the mean methylation level was significantly decreased in lung SCC. We also identified methylation-driven genes which were associated with cancer-related pathways. The multivariate Cox regression analysis showed four methylation-driven genes, GCSAM, GPR75, NHLRC1, and TRIM58, could be served as prognostic indicators for lung SCC. Validation on two external GEO datasets showed consistent methylation alterations of the four genes. These findings may have important implications in the understanding of the potential therapeutic method for lung SCC.
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