Evidence map›Paper›PMID 31105769›Full record

ReviewTherapeutic advances in neurological disorders2019

Advances in cerebral amyloid angiopathy imaging.

Szu-Ju Chen, Hsin-Hsi Tsai, Li-Kai Tsai, Sung-Chun Tang, Bo-Chin Lee, Hon-Man Liu, Ruoh-Fang Yen, Jiann-Shing Jeng

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in neurological disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05207475 (Safety and Efficacy of Remote Ischemic Conditioning in Patients With Cerebral Amyloid Angiopathy), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05207475 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Safety and Efficacy of Remote Ischemic Conditioning in Patients With Cerebral Amyloid Angiopathy: A Prospective, Randomized, Controlled Study

TypeinterventionalSponsorCapital Medical UniversityRan2022 to 2022Enrolled30ConditionsCerebral Amyloid AngiopathyArmsRemote ischemic conditioning
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Imaging of Spontaneous Intracerebral Hemorrhage.Neuroimaging clinics of North America · 2021
    Review
  11. Article
  12. The Neurovascular Unit Dysfunction in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  13. Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Szu-Ju ChenDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan Department of Neurology, En Chu Kong Hospital, New Taipei City, Taiwan.
Hsin-Hsi TsaiDepartment of Neurology, National Taiwan University Hospital Bei-Hu Branch, No. 87, Neijiang Street, Taipei, 10845, Taiwan.
Li-Kai TsaiDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Sung-Chun TangDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Bo-Chin LeeDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Hon-Man LiuDepartment of Medical Imaging, Fu-Jen Catholic University Hospital, New Taipei City, Taiwan.
Ruoh-Fang YenDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Jiann-Shing JengDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
National Taiwan University Hospital · TWFu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease caused by β -amyloid (Aβ) deposition at the leptomeningeal vessel walls. It is a common cause of spontaneous intracerebral hemorrhage and a frequent comorbidity in Alzheimer's disease. The high recurrent hemorrhage rate in CAA makes it very important to recognize this disease to avoid potential harmful medication. Imaging studies play an important role in diagnosis and research of CAA. Conventional computed tomography and magnetic resonance imaging (MRI) methods reveal anatomical alterations, and remains as the most reliable tool in identifying CAA according to modified Boston criteria. The vascular injuries of CAA result in both hemorrhagic and ischemic manifestations and related structural changes on MRI, including cerebral microbleeds, cortical superficial siderosis, white matter hyperintensity, MRI-visible perivascular spaces, and cortical microinfarcts. As imaging techniques advance, not only does the resolution of conventional imaging improve, but novel skills in functional and molecular imaging studies also enable

Indexed as

cerebral amyloid angiopathycerebral microbleedmagnetic resonance imagingpositron emitting tomographysmall vessel disease

Identifiers

PMID31105769
PMCPMC6501479
OpenAlexW2942835550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.