Evidence map›Paper›PMID 31105710›Full record

ArticleFrontiers in immunology2019

Diet Rich in Animal Protein Promotes Pro-inflammatory Macrophage Response and Exacerbates Colitis in Mice.

Klara Kostovcikova, Stepan Coufal, Natalie Galanova, Alena Fajstova, Tomas Hudcovic, Martin Kostovcik, Petra Prochazkova, Zuzana Jiraskova Zakostelska, Martina Cermakova, Blanka Sediva and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Plant and Animal Protein Sources in Inflammatory Bowel Disease: Current Evidence and Clinical Implications.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
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  11. NF-κB in inflammation and cancer.Cellular & molecular immunology · 2025
    Review
  12. Article
  13. Article
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  17. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Klara KostovcikovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Stepan CoufalLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Natalie GalanovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Alena FajstovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Tomas HudcovicLaboratory of Gnotobiology, Institute of Microbiology of the CAS, v.v.i., Nový Hrádek, Czechia.
Martin KostovcikLaboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Petra ProchazkovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Zuzana Jiraskova ZakostelskaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Martina CermakovaLaboratory of Molecular Structure Characterization, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Blanka SedivaLaboratory of Molecular Structure Characterization, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Marek KuzmaLaboratory of Molecular Structure Characterization, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Helena Tlaskalova-HogenovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Miloslav KverkaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the CAS, v.v.i., Prague, Czechia.
Czech Academy of Sciences, Institute of Microbiology · CZUniversity of West Bohemia · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet is a major factor determining gut microbiota composition and perturbances in this complex ecosystem are associated with the inflammatory bowel disease (IBD). Here, we used gnotobiotic approach to analyze, how interaction between diet rich in proteins and gut microbiota influences the sensitivity to intestinal inflammation in murine model of ulcerative colitis. We found that diet rich in animal protein (aHPD) exacerbates acute dextran sulfate sodium (DSS)-induced colitis while diet rich in plant protein (pHPD) does not. The deleterious effect of aHPD was also apparent in chronic DSS colitis and was associated with distinct changes in gut bacteria and fungi. Therefore, we induced acute DSS-colitis in germ-free mice and transferred gut microbiota from aCD or aHPD fed mice to find that this effect requires presence of microbes and aHPD at the same time. The aHPD did not change the number of regulatory T cells or Th17 cells and still worsened the colitis in immuno-deficient RAG2 knock-out mice suggesting that this effect was not dependent on adaptive immunity. The pro-inflammatory effect of aHPD was, however, abrogated when splenic macrophages were depleted with clodronate liposomes. This treatment prevented aHPD induced increase in colonic Ly-6C

Indexed as

Adaptive ImmunityAnimalsColitisColonDietDietary ProteinsDisease Models, AnimalDNA-Binding ProteinsFemaleGastrointestinal MicrobiomeInflammationIntestinesMacrophagesMiceMice, Inbred BALB CMice, KnockoutDietary ProteinsDNA-Binding Proteinscolitisdietary proteingerm-freemacrophagemicrobiota

Identifiers

PMID31105710
PMCPMC6497971
OpenAlexW2940891270

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.