Evidence map›Paper›PMID 31105705›Full record

ArticleFrontiers in immunology2019

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for

Menno C van Zelm, Marsus Pumar, Peter Shuttleworth, Pei M Aui, Joanne M Smart, Andrew Grigg, Julian J Bosco

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Revisiting X-linked agammaglobulinemia.Journal of human immunity · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Menno C van ZelmDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Marsus PumarAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology Research, Central Clinical School, The Alfred Hospital, Melbourne, VIC, Australia.
Peter ShuttleworthDepartment of Clinical Haematology and Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia.
Pei M AuiDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Joanne M SmartThe Jeffrey Modell Diagnostic and Research Centre for Primary Immunodeficiencies, Melbourne, VIC, Australia.
Andrew GriggDepartment of Clinical Haematology and Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia.
Julian J BoscoAllergy, Asthma and Clinical Immunology Service, Department of Respiratory, Allergy and Clinical Immunology Research, Central Clinical School, The Alfred Hospital, Melbourne, VIC, Australia.
Austin Health · AUJeffrey Modell Foundation · AUThe Alfred Hospital · AURoyal Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with X-linked agammaglobulinemia (XLA) have failure of B-cell development with lack of immunoglobulin (Ig) production. While immunoglobulin replacement therapy (IgRT) is beneficial, XLA patients remain at risk for infections, structural lung damage, and rarely, neoplasia. Allogeneic stem cell transplantation (alloSCT) may offer a potential cure, but is associated with significant life-threatening complications. Here, we present a 25-year old XLA patient who developed pre-B acute lymphocytic leukemia (ALL) with somatic

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgammaglobulinemiaCyclosporineGenetic Diseases, X-LinkedGraft vs Host DiseaseHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunosuppressive AgentsMalePrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrednisoloneTransplantation ConditioningTumor Suppressor Protein p53CyclosporineImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunosuppressive AgentsPrednisoloneTP53 protein, humanTumor Suppressor Protein p53allogeneic stem cell transplantationBTKIgGpre-B-ALLvaccination responseX-linked agammaglobulinemia

Identifiers

PMID31105705
PMCPMC6498405
OpenAlexW2941613119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.