Evidence map›Paper›PMID 31105703›Full record

ArticleFrontiers in immunology2019

Restored and Enhanced Memory T Cell Immunity in Rheumatoid Arthritis After TNFα Blocker Treatment.

Asma Khanniche, Ling Zhou, Bin Jiang, Jing Song, Yanhua Jin, Jian Yin, Shujun Wang, Ping Ji, Hao Shen, Ying Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. MALT1 regulates Th2 and Th17 differentiationFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Asma KhannicheShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ling ZhouDepartment of Rheumatology and Immunology, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
Bin JiangDepartment of Rheumatology, Renji Hospital, Shanghai, China.
Jing SongDepartment of Rheumatology and Immunology, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
Yanhua JinDepartment of Rheumatology and Immunology, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
Jian YinDepartment of Rheumatology and Immunology, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
Shujun WangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ping JiShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao ShenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Ying WangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huji XuDepartment of Rheumatology and Immunology, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
Second Military Medical University · CNShanghai Jiao Tong University · CNCenter for Life Sciences · CNRenji Hospital · CNShenzhen Institutes of Advanced Technology · CNUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TNFα inhibitors have shaped the landscape of rheumatoid arthritis (RA) therapy with high clinical efficiency. However, their impact on T cell recall responses is not well-elucidated. We aimed to analyze the immune profiles of memory T cells in RA patients undergoing TNFα inhibitor Golimumab (GM) treatment. Frequencies of peripheral T cell subsets and cytokine expression profiles in memory T cells (T

Indexed as

Immunologic MemoryAdultAgedAllelesAntibodies, MonoclonalArthritis, RheumatoidCytokinesDisease ManagementDisease SusceptibilityFemaleHLA-A2 AntigenHumansImmunophenotypingMaleMiddle AgedT-LymphocytesAntibodies, MonoclonalCytokinesgolimumabHLA-A2 AntigenTumor Necrosis Factor-alphaTumor Necrosis Factor Inhibitorsantigen specificimmune regulationmemory T cellsrheumatoid arthritisTNFα inhibitor

Identifiers

PMID31105703
PMCPMC6499160
OpenAlexW2941937307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.