Evidence map›Paper›PMID 31105633›Full record

ArticleFrontiers in neurology2019

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease.

Tracy R Melzer, Megan R Stark, Ross J Keenan, Daniel J Myall, Michael R MacAskill, Toni L Pitcher, Leslie Livingston, Sophie Grenfell, Kyla-Louise Horne, Bob N Young and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Thalamic nuclei insights into Alzheimer's disease.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Impact of 6-OHDA injection and microtrauma in the ratHistology and histopathology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Acquired Stuttering in Parkinson's Disease.Movement disorders clinical practice · 2023
    Article
  20. The consequences of sleep deprivation on cognitive performance.Neurosciences (Riyadh, Saudi Arabia) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Tracy R MelzerNew Zealand Brain Research Institute, Christchurch, New Zealand.
Megan R StarkNew Zealand Brain Research Institute, Christchurch, New Zealand.
Ross J KeenanNew Zealand Brain Research Institute, Christchurch, New Zealand.
Daniel J MyallNew Zealand Brain Research Institute, Christchurch, New Zealand.
Michael R MacAskillNew Zealand Brain Research Institute, Christchurch, New Zealand.
Toni L PitcherNew Zealand Brain Research Institute, Christchurch, New Zealand.
Leslie LivingstonNew Zealand Brain Research Institute, Christchurch, New Zealand.
Sophie GrenfellNew Zealand Brain Research Institute, Christchurch, New Zealand.
Kyla-Louise HorneNew Zealand Brain Research Institute, Christchurch, New Zealand.
Bob N YoungNew Zealand Brain Research Institute, Christchurch, New Zealand.
Maddie J PascoeNew Zealand Brain Research Institute, Christchurch, New Zealand.
Mustafa M AlmuqbelNew Zealand Brain Research Institute, Christchurch, New Zealand.
Jian WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Steven H MarshDepartment of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand.
David H MillerNew Zealand Brain Research Institute, Christchurch, New Zealand.
John C Dalrymple-AlfordNew Zealand Brain Research Institute, Christchurch, New Zealand.
Tim J AndersonNew Zealand Brain Research Institute, Christchurch, New Zealand.
New Zealand Brain Research Institute · NZUniversity of Canterbury · NZUniversity of Otago · NZBrain Research New Zealand · NZChristchurch Hospital · NZFudan University · CNUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extent to which Alzheimer neuropathology, particularly the accumulation of misfolded beta-amyloid, contributes to cognitive decline and dementia in Parkinson's disease (PD) is unresolved. Here, we used Florbetaben PET imaging to test for any association between cerebral amyloid deposition and cognitive impairment in PD, in a sample enriched for cases with mild cognitive impairment. This cross-sectional study used Movement Disorders Society level II criteria to classify 115 participants with PD as having normal cognition (PDN,

Indexed as

amyloid PETcentiloiddementiaFlorbetabenmild cognitive impairmentParkinson's disease

Identifiers

PMID31105633
PMCPMC6492461
OpenAlexW2940810421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.