Evidence map›Paper›PMID 31105630›Full record

SynthesisFrontiers in neurology2019

Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review.

Priscila Cunha Nascimento, Micaele Maria Lopes Castro, Marcela Baraúna Magno, Anna Paula Costa Ponte Sousa Carvalho Almeida, Nathália Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 8 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 8 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Lead exposure and its association with neurological damage: systematic review and meta-analysis.Environmental science and pollution research international · 2021
    Pooled it
  7. Pooled it
  8. Association Between Periodontitis and Mild Cognitive Impairment, Alzheimer's Disease, and Dementia: An Umbrella Review With Evidence Stratification.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Pooled it
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
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  15. Article
  16. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Priscila Cunha NascimentoLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Brazil.
Micaele Maria Lopes CastroLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Brazil.
Marcela Baraúna MagnoDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Anna Paula Costa Ponte Sousa Carvalho AlmeidaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Brazil.
Nathália Carolina Fernandes FagundesSchool of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Lucianne Cople MaiaDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belém, Brazil.
Universidade Federal do Pará · BRUniversidade Federal do Rio de Janeiro · BRUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between periodontitis and mild cognitive impairment or dementia. The purpose of this study was to evaluate the clinical/epidemiological evidence regarding the association between periodontitis and cognitive decline in adult patients. A search conducted between September and October 2018 was performed in the electronic databases PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey, and Google Scholar, with no publication date or language restrictions. Analytical observational studies in adults (P-Participants), with (E-Exposure) and without periodontitis (C-Comparison) were included in order to determine the association between periodontitis and cognitive decline (O-Outcome). The search identified 509 references, of which eight observational studies were accorded with the eligibility criteria and evaluated. The results should, however, be interpreted cautiously due to the limited number of studies. This systematic review points to the need for further well-designed studies, such as longitudinal observational studies with control of modifiable variables, as diagnostic criteria and time since diagnosis of periodontitis and cognitive impairment, to confirm the proposed association.

Indexed as

cognitive dysfunctioncognitive impairmentdementiaoral healthperiodontitissystematic review

Identifiers

PMID31105630
PMCPMC6492457
OpenAlexW2942298034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.