ArticleFrontiers in neuroscience2019
Optimal Electrode Size for Multi-Scale Extracellular-Potential Recording From Neuronal Assemblies.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
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- Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings.Microsystems & nanoengineering · 2026Article
- Robust minimally-invasive microfabricated stainless steel neural interfaces for high resolution recording.Nature communications · 2026Article
- Direct laser carbonization of parylene-C toward microelectrodes forFrontiers in neuroscience · 2026Article
- UV Laser-Induced Carbon Microelectrode Arrays for Neuronal Recordings.Advanced healthcare materials · 2025Article
- Co-cultured sensory neuron classification using extracellular electrophysiology and machine learning approaches for enhancing analgesic screening.Journal of neural engineering · 2025Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
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- Wearable Biodevices Based on Two-Dimensional Materials: From Flexible Sensors to Smart Integrated Systems.Nano-micro letters · 2025Review
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- Mechanically-adaptive, resveratrol-eluting neural probes for improved intracortical recording performance and stability.Npj flexible electronics · 2025Article
- Electrode Surface Area Impacts Measurement of High Frequency Oscillations in Human Intracranial EEG.IEEE transactions on bio-medical engineering · 2024Article
- Array-wide uniform PEDOT:PSS electroplating from potentiostatic deposition.Biosensors & bioelectronics · 2024Article
- Multifunctional Nanomesh Enables Cellular-Resolution, Elastic Neuroelectronics.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Impact of Impedance Levels on Recording Quality in Flexible Neural Probes.Sensors (Basel, Switzerland) · 2024Article
- High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings.Nature nanotechnology · 2024Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in microfabrication technology have enabled the production of devices containing arrays of thousands of closely spaced recording electrodes, which afford subcellular resolution of electrical signals in neurons and neuronal networks. Rationalizing the electrode size and configuration in such arrays demands consideration of application-specific requirements and inherent features of the electrodes. Tradeoffs among size, spatial density, sensitivity, noise, attenuation, and other factors are inevitable. Although recording extracellular signals from neurons with planar metal electrodes is fairly well established, the effects of the electrode characteristics on the quality and utility of recorded signals, especially for small, densely packed electrodes, have yet to be fully characterized. Here, we present a combined experimental and computational approach to elucidating how electrode size, and size-dependent parameters, such as impedance, baseline noise, and transmission characteristics, influence recorded neuronal signals. Using arrays containing platinum electrodes of different sizes, we experimentally evaluated the electrode performance in the recording of local field potentials (LFPs) and extracellular action potentials (EAPs) from the following cell preparations: acute brain slices, dissociated cell cultures, and organotypic slice cultures. Moreover, we simulated the potential spatial decay of point-current sources to investigate signal averaging using known signal sources. We demonstrated that the noise and signal attenuation depend more on the electrode impedance than on electrode size,
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