ArticleDose-response : a publication of International Hormesis Society
The Potential Effect of Different Doses of Ionizing Radiation on Genes and Disease.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Telomere fragility in radiology workers occupationally exposed to low doses of ionising radiation.Arhiv za higijenu rada i toksikologiju · 2022Article
- Genome-Wide DNA Alterations in X-Irradiated Human Gingiva Fibroblasts.International journal of molecular sciences · 2020Article
- Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe chromosomal aberrations induced by radiation appear about nonrandomly distributed across the whole genome. Previous studies have shown that chromosomes with high DNA content are less frequently involved in the formation of symmetrical translocations and dicentric chromosomes than expected, whereas smaller chromosomes are more frequently involved. We hypothesized that these translocation regions are linked to radiation sensitivity. MATERIALS AND
methodsWe investigated the frequencies of chromosome translocations induced by radiation exposure and adjusted the results according to chromosome length. We specifically analyzed whole blood samples from 3 participants. The samples were irradiated using
resultsOur analysis indicated that chromosomes 9q were the most sensitive to translocations after various doses of radiation, and such translocations occurred in the euchromatin region. Chromosomes 1, 9, 15, and 17 were more sensitive to radiation doses of 0.5 Gy. This observation could be useful when selecting sensitive reference chromosomes in the low-dose region. The results of expression profiling analysis for radiation-sensitive regions were similar to those of chromosome translocation analysis.
conclusionThis study shows that some chromosomes or genomic regions are more sensitive to alteration by radiation exposure.
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Registered trials
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