Evidence map›Paper›PMID 31105464›Full record

ArticleBiochemical engineering journal2019

Loading and Releasing Ciprofloxacin in Photoactivatable Liposomes.

Sanjana Ghosh, Ruiquan Qi, Kevin A Carter, Guojian Zhang, Blaine A Pfeifer, Jonathan F Lovell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical engineering journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Drug delivery strategies for antibiofilm therapy.Nature reviews. Microbiology · 2023
    Review
  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sanjana GhoshDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
Ruiquan QiDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
Kevin A CarterDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
Guojian ZhangDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
Blaine A PfeiferDepartment of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, 14260, USA.
University at Buffalo, State University of New York · US

Funding

Light-Triggered Drug Release in Primed Pancreatic TumorsR01EB017270 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2021
$3.5M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
NIBIB NIH HHS R01 EB017270NIH HHS DP5 OD017898
6 · The paper itself

Abstract

We demonstrate that ciprofloxacin can be actively loaded into liposomes that contain small amounts of porphyrin-phospholipid (PoP). PoP renders the liposomes photoactivatable, so that the antibiotic is released from the carrier under red light irradiation (665 nm). The use of 2 molar % PoP in the liposomes accommodated active loading of ciprofloxacin. Further inclusion of 2 molar % of an unsaturated phospholipid accelerated light-triggered drug release, with more than 90 % antibiotic release from the liposomes occurring in less than 30 seconds. With or without laser treatment, ciprofloxacin PoP liposomes inhibited the growth of

Indexed as

AntibioticsCiprofloxacinDrug deliveryLight triggered releaseLiposomesPorphyrin-phospholipid

Identifiers

PMID31105464
PMCPMC6519738
OpenAlexW2897470124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.