ArticleProceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science2018
Numerical simulation of cell squeezing through a micropore by the immersed boundary method.
Article in Proceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Computational analysis of cancer cell adhesion in curved vessels affected by wall shear stress for prediction of metastatic spreading.Frontiers in bioengineering and biotechnology · 2024Article
- Experimental measurement and numerical modeling of deformation behavior of breast cancer cells passing through constricted microfluidic channels.Microsystems & nanoengineering · 2024Article
- Numerical Modeling of Physical Cell Trapping in Microfluidic Chips.Micromachines · 2023Article
- Blood Viscosity in Subjects With Type 2 Diabetes Mellitus: Roles of Hyperglycemia and Elevated Plasma Fibrinogen.Frontiers in physiology · 2022Article
- A systematic approach for developing mechanistic models for realistic simulation of cancer cell motion and deformation.Scientific reports · 2021Article
- Numerical simulation of intracellular drug delivery via rapid squeezing.Biomicrofluidics · 2021Article
- 3D Printing metamaterials towards tissue engineering.Applied materials today · 2020Article
- Multiscale modeling of hemolysis during microfiltration.Microfluidics and nanofluidics · 2020Article
- Review on Microbubbles and Microdroplets Flowing through Microfluidic Geometrical Elements.Micromachines · 2020Review
- Simulation of circulating tumor cell transport and adhesion in cell suspensions in microfluidic devices.Biomicrofluidics · 2019Article
- Label-free sorting of soft microparticles using a bioinspired synthetic cilia array.Biomicrofluidics · 2018Article
- A parallel fluid-solid coupling model usingJournal of computational science · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The deformability of cells has been used as a biomarker to detect circulating tumor cells (CTCs) from patient blood sample using microfluidic devices with microscale pores. Successful separations of CTCs from a blood sample requires careful design of the micropore size and applied pressure. This paper presented a parametric study of cell squeezing through micropores with different size and pressure. Different membrane compressibility modulus was used to characterize the deformability of varying cancer cells. Nucleus effect was also considered. It shows that the cell translocation time though the micropore increases with cell membrane compressibility modulus and nucleus stiffness. Particularly, it increases exponentially as the micropore diameter or pressure decreases. The simulation results such as the cell squeezing shape and translocation time agree well with experimental observations. The simulation results suggest that special care should be taken in applying Laplace-Young equation (LYE) to microfluidic design due to the nonuniform stress distribution and membrane bending resistance.
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Registered trials
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