Evidence map›Paper›PMID 31105244›Full record

ArticleBiomimetics (Basel, Switzerland)2018

Biosafety of Mesoporous Silica Nanoparticles.

Estelle Rascol, Cédric Pisani, Christophe Dorandeu, Jeff L Nyalosaso, Clarence Charnay, Morgane Daurat, Afitz Da Silva, Jean-Marie Devoisselle, Jean-Charles Gaillard, Jean Armengaud and 6 more

Abstract read
In one paragraph

Article in Biomimetics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Estelle RascolInstitute of Chemistry and Biology of Membranes and Nano-objects (CBMN) UMR-5248, CNRS, University of Bordeaux, INP, Allée Geoffroy St Hilaire, 33600 Pessac, France. estelle.rascol.c2i12@gmail.com.
Cédric PisaniThe French Alternative Energies and Atomic Energy Commission (CEA), Biosciences and Biotechnologies Institute (BIAM), 30200 Bagnols-sur-Cèze, France. pisani.cedric@gmail.com.
Christophe DorandeuInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. christophe.dorandeu@umontpellier.fr.
Jeff L NyalosasoInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. jeff.nyalosaso@gmail.com.
Clarence CharnayInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. clarence.charnay@univ-montp2.fr.
Morgane DauratNanoMedSyn, 15 Avenue Charles Flahault, 34090 Montpellier, France. morgane.daurat2@gmail.com.
Afitz Da SilvaNanoMedSyn, 15 Avenue Charles Flahault, 34090 Montpellier, France. afitz@hotmail.fr.
Jean-Marie DevoisselleInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. jm.devoisselle@univ-montp1.fr.
Jean-Charles GaillardLaboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, 30207 Bagnols-sur-Cèze, France. jean-charles.gaillard@cea.fr.
Jean ArmengaudLaboratoire Innovations technologiques pour la Détection et le Diagnostic (Li2D), Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, 30207 Bagnols-sur-Cèze, France. jean.armengaud@cea.fr.
Odette PratThe French Alternative Energies and Atomic Energy Commission (CEA), Biosciences and Biotechnologies Institute (BIAM), 30200 Bagnols-sur-Cèze, France. odette.prat@cea.fr.
Marie MaynadierNanoMedSyn, 15 Avenue Charles Flahault, 34090 Montpellier, France. m.maynadier@nanomedsyn.com.
Magali Gary-BoboMax Mousseron Biomolecule Institute of Montpellier (IBMM), 15 Avenue Charles Flahault, 34090 Montpellier, France. magali.gary-bobo@inserm.fr.
Marcel GarciaNanoMedSyn, 15 Avenue Charles Flahault, 34090 Montpellier, France. m.garcia@nanomedsyn.com.
Joël ChopineauInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. joel.chopineau@enscm.fr.
Yannick GuariInstitute Charles Gerhardt of Montpellier (ICGM), Place E. Bataillon, 34095 Montpellier, France. yannick.guari@univ-montp2.fr.

Funding

French National Research Agency ANR-13-NANO-0007, BioSiPharm project
6 · The paper itself

Abstract

Careful analysis of any new nanomedicine device or disposal should be undertaken to comprehensively characterize the new product before application, so that any unintended side effect is minimized. Because of the increasing number of nanotechnology-based drugs, we can anticipate that regulatory authorities might adapt the approval process for nanomedicine products due to safety concerns, e.g., request a more rigorous testing of the potential toxicity of nanoparticles (NPs). Currently, the use of mesoporous silica nanoparticles (MSN) as drug delivery systems is challenged by a lack of data on the toxicological profile of coated or non-coated MSN. In this context, we have carried out an extensive study documenting the influence of different functionalized MSN on the cellular internalization and in vivo behaviour. In this article, a synthesis of these works is reviewed and the perspectives are drawn. The use of magnetic MSN (Fe

Indexed as

adverse outcome pathwaysinternalizationmesoporous silicananoparticlesprotein coronasafety

Identifiers

PMID31105244
PMCPMC6352691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.